caa a22 4500 445312718 CHVBK 20180317142635.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s11095-011-0550-2 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0550-2 The Therapeutic Potential of MicroRNAs: Disease Modulators and Drug Targets [Elektronische Daten] [Ailbhe McDermott, Helen Heneghan, Nicola Miller, Michael Kerin] ABSTRACT: MiRNAs are a class of small, naturally occurring RNA molecules that play critical roles in modulating numerous biological pathways by regulating gene expression. The knowledge that miRNA expression is dysregulated in many pathological disease processes, including cancer, has led to a rapidly expanding body of literature as we try to unveil their mechanism of action. Their putative role as oncogenes or tumour suppressor genes presents a wonderful opportunity to provide targeted cancer treatment strategies. Additionally, their documented function in a host of benign diseases broadens the potential market for miRNA-based therapeutics. The present review outlines the underlying rationales for considering mi(cro)RNAs as therapeutic agents or targets. We highlight the potential of manipulating miRNAs for the treatment of many common diseases, particularly cancers. Finally, we summarize the challenges that need to be overcome to fully harness the potential of miRNA-based therapies so they become the next generation of pharmaceutical products. Springer Science+Business Media, LLC, 2011 miRNA manipulation nationallicence miRNA therapeutics nationallicence oncomirs nationallicence tumor supressors nationallicence AGO : argonaute nationallicence amiRNA : artificial microRNA nationallicence AML : acute myeloid leukemia nationallicence AMO : anti-miRNA oligonucleotide nationallicence ECM : extracellular matrix nationallicence ER : estrogen receptor nationallicence HBV : hepatitis B virus nationallicence HCC : hepatocellular carcinoma nationallicence HCV : hepatitis C virus nationallicence HO-1 : heme oxygenase-1 nationallicence HSC : hepatic stellate cells nationallicence LNA : locked nucleic acids nationallicence MCL : mantle cell lymphoma nationallicence miRAGE : miRNA serial analysis of gene expression nationallicence miRISC : miRNA-associated RNA-induced silencing complex nationallicence miRNA : microRNA nationallicence mRNA : messenger RNA nationallicence NSCLC : non-small-cell lung cancer nationallicence PAMAM : polyamidoamine nationallicence PR : progesterone receptor nationallicence RAKE : RNA-primed array-based Klenow enzyme nationallicence SAGE : serial analysis of gene expression nationallicence SERM : selective estrogen receptor modulator nationallicence TGFß : transforming growth factor beta nationallicence UTR : untranslated region nationallicence McDermott Ailbhe Surgery, School of Medicine, National University of Ireland, Galway, Ireland aut Heneghan Helen Surgery, School of Medicine, National University of Ireland, Galway, Ireland aut Miller Nicola Surgery, School of Medicine, National University of Ireland, Galway, Ireland aut Kerin Michael Surgery, School of Medicine, National University of Ireland, Galway, Ireland aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/12(2011-12-01), 3016-3029 0724-8741 28:12<3016 2011 28 11095 https://doi.org/10.1007/s11095-011-0550-2 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0550-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McDermott Ailbhe Surgery, School of Medicine, National University of Ireland, Galway, Ireland aut NATIONALLICENCE 700 1- Heneghan Helen Surgery, School of Medicine, National University of Ireland, Galway, Ireland aut NATIONALLICENCE 700 1- Miller Nicola Surgery, School of Medicine, National University of Ireland, Galway, Ireland aut NATIONALLICENCE 700 1- Kerin Michael Surgery, School of Medicine, National University of Ireland, Galway, Ireland aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/12(2011-12-01), 3016-3029 0724-8741 28:12<3016 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer