caa a22 4500 445312971 CHVBK 20180317142636.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s11095-010-0319-z doi (NATIONALLICENCE)springer-10.1007/s11095-010-0319-z A Smart Interface for Reliable Intradermal Injection and Infusion of High and Low Viscosity Solutions [Elektronische Daten] [Michael Vosseler, Michael Jugl, Roland Zengerle] ABSTRACT: Purpose: We present a smart intradermal interface suitable for skin-attached drug delivery devices. Our solution enables injections or infusions that are less invasive compared to subcutaneous injections and are leakage-free at the location of penetration. Methods: The intradermal interface is based on a 31-gauge cannula embedded in a slider, movable relative to a carrier plate that can easily be fixed onto the skin. By simply pushing the slider, the cannula is inserted into the dermis. Results: We performed injections and infusions with stained water and polyethylene glycol (PEG) solution in ex vivo pig skin. The sizes of coloured spots in the skin range from 3.5mm2 to 15.4mm2 for stained water depending on the infused volume. Infusing stained PEG solution resulted in stained tissue areas about one order of magnitude larger. One of three investigated leakage modes is unacceptable but can be reliably avoided by proper site selection. At low flow rates and at the beginning of an infusion an initial back pressure overshoot was identified. This effect was identified as the limiting parameter for the design of small programmable or intelligent devices based on micro actuators. Conclusions: With the proposed easy-to-use interface, intradermal injections and infusions can be performed reliably. Therefore, it is supposed to be an ideal and clinically relevant solution for self-administration of parenteral drugs in home care applications. Springer Science+Business Media, LLC, 2010 drug delivery nationallicence infusion nationallicence injection nationallicence intradermal nationallicence microneedle nationallicence Vosseler Michael HSG-IMIT, Wilhelm-Schickard-Str. 10, 78052, Villingen-Schwenningen, Germany aut Jugl Michael HSG-IMIT, Wilhelm-Schickard-Str. 10, 78052, Villingen-Schwenningen, Germany aut Zengerle Roland HSG-IMIT, Wilhelm-Schickard-Str. 10, 78052, Villingen-Schwenningen, Germany aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/3(2011-03-01), 647-661 0724-8741 28:3<647 2011 28 11095 https://doi.org/10.1007/s11095-010-0319-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-010-0319-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vosseler Michael HSG-IMIT, Wilhelm-Schickard-Str. 10, 78052, Villingen-Schwenningen, Germany aut NATIONALLICENCE 700 1- Jugl Michael HSG-IMIT, Wilhelm-Schickard-Str. 10, 78052, Villingen-Schwenningen, Germany aut NATIONALLICENCE 700 1- Zengerle Roland HSG-IMIT, Wilhelm-Schickard-Str. 10, 78052, Villingen-Schwenningen, Germany aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/3(2011-03-01), 647-661 0724-8741 28:3<647 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer