caa a22 4500 445313188 CHVBK 20180317142637.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s11095-011-0449-y doi (NATIONALLICENCE)springer-10.1007/s11095-011-0449-y Controlled Release Systems Containing Solid Dispersions: Strategies and Mechanisms [Elektronische Daten] [Phuong Tran, Thao Tran, Jun Park, Beom-Jin Lee] ABSTRACT: In addition to a number of highly soluble drugs, most new chemical entities under development are poorly water-soluble drugs generally characterized by an insufficient dissolution rate and a small absorption window, leading to the low bioavailability. Controlled-release (CR) formulations have several potential advantages over conventional dosage forms, such as providing a uniform and prolonged therapeutic effect to improve patient compliance, reducing the frequency of dosing, minimizing the number of side effects, and reducing the strength of the required dose while increasing the effectiveness of the drug. Solid dispersions (SD) can be used to enhance the dissolution rate of poorly water-soluble drugs and to sustain the drug release by choosing an appropriate carrier. Thus, a CR-SD comprises both functions of SD and CR for poorly water-soluble drugs. Such CR dosage forms containing SD provide an immediately available dose for an immediate action followed by a gradual and continuous release of subsequent doses to maintain the plasma concentration of poorly water-soluble drugs over an extended period of time. This review aims to summarize all currently known aspects of controlled release systems containing solid dispersions, focusing on the preparation methods, mechanisms of action and characterization of physicochemical properties of the system. Springer Science+Business Media, LLC, 2011 controlled release solid dispersion nationallicence poorly water-soluble drugs nationallicence manufacturing methods nationallicence physicochemical characterization nationallicence rate-controlling mechanism nationallicence AAS : atomic absorption spectroscopy nationallicence AES : atomic emission spectroscopy nationallicence CLSM : confocal laser scanning microscopy nationallicence CR : controlled release nationallicence CR-SD : controlled-release solid dispersion nationallicence DSC : differential scanning calorimetry nationallicence EC : ethylcellulose nationallicence EPRI : electron paramagnetic resonance imaging nationallicence FTIR : fourier transformed infrared spectroscopy nationallicence HPMC : hydroxypropyl methylcellulose nationallicence HEC : hydroxyethyl cellulose nationallicence HPC : hydroxypropyl cellulose nationallicence ICP spectrometry : inductively coupled plasma spectrometry nationallicence IR-SD : immediate-release solid dispersion nationallicence MRI : magnetic resonance imaging nationallicence NIR imaging : near infrared imaging nationallicence NMR : nuclear magnetic resonance nationallicence NSESD : non-self-emulsifying solid dispersion nationallicence PCS : photon correlation spectroscopy nationallicence PEG : polyethylene glycol nationallicence PEO : polyethylene oxide nationallicence PVP : polyvinyl pyrrolidone nationallicence pHM : microenvironmental pH nationallicence PXRD : powder X-ray diffraction nationallicence SD : solid dispersion nationallicence SEM : scanning electron microscopy nationallicence SESD : self-emulsifying solid dispersion nationallicence TEM : transmission electron microscopy nationallicence Tg : glass transition temperature nationallicence TMDSC : temperature modulated differential scanning calorimetry nationallicence Tran Phuong Bioavailability Control Laboratory, College of Pharmacy, Kangwon National University, 1 University Road, Hyoja-Dong, 200-701, Chuncheon, Republic of Korea aut Tran Thao Bioavailability Control Laboratory, College of Pharmacy, Kangwon National University, 1 University Road, Hyoja-Dong, 200-701, Chuncheon, Republic of Korea aut Park Jun Bioavailability Control Laboratory, College of Pharmacy, Kangwon National University, 1 University Road, Hyoja-Dong, 200-701, Chuncheon, Republic of Korea aut Lee Beom-Jin Bioavailability Control Laboratory, College of Pharmacy, Kangwon National University, 1 University Road, Hyoja-Dong, 200-701, Chuncheon, Republic of Korea aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/10(2011-10-01), 2353-2378 0724-8741 28:10<2353 2011 28 11095 https://doi.org/10.1007/s11095-011-0449-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0449-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tran Phuong Bioavailability Control Laboratory, College of Pharmacy, Kangwon National University, 1 University Road, Hyoja-Dong, 200-701, Chuncheon, Republic of Korea aut NATIONALLICENCE 700 1- Tran Thao Bioavailability Control Laboratory, College of Pharmacy, Kangwon National University, 1 University Road, Hyoja-Dong, 200-701, Chuncheon, Republic of Korea aut NATIONALLICENCE 700 1- Park Jun Bioavailability Control Laboratory, College of Pharmacy, Kangwon National University, 1 University Road, Hyoja-Dong, 200-701, Chuncheon, Republic of Korea aut NATIONALLICENCE 700 1- Lee Beom-Jin Bioavailability Control Laboratory, College of Pharmacy, Kangwon National University, 1 University Road, Hyoja-Dong, 200-701, Chuncheon, Republic of Korea aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/10(2011-10-01), 2353-2378 0724-8741 28:10<2353 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer