caa a22 4500 445313196 CHVBK 20180317142637.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s11095-011-0450-5 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0450-5 Preparation of Personalized-dose Salbutamol Sulphate Oral Films with Thermal Ink-Jet Printing [Elektronische Daten] [Asma Buanz, Mark Saunders, Abdul Basit, Simon Gaisford] ABSTRACT: Purpose: To evaluate the use of thermal ink-jetting as a method for dosing drugs onto oral films. Methods: A Hewlett-Packard printer cartridge was modified so that aqueous drug solutions replaced the ink. The performance of the printer as a function of print solution viscosity and surface tension was determined; viscosities between 1.1 and 1.5mm2 s-1 were found to be optimal, while surface tension did not affect deposition. A calibration curve for salbutamol sulphate was prepared, which demonstrated drug deposition onto an acetate film varied linearly with concentration (r2 = 0.9992). The printer was then used to deposit salbutamol sulphate onto an oral film made of potato starch. Results: It was found that when doses were deposited in a single pass under the print head, then the measured dose was in good agreement with the theoretical dose. With multiple passes the measured dose was always significantly less than the theoretical dose. It is proposed that the losses arise from erosion of the printed layer by shearing forces during paper handling. The losses were predictable, and the variance in dose deposited was always less than the BP limits for tablet and oral syrup salbutamol sulphate preparations. Conclusions: TIJ printing offers a rapid method for extemporaneous preparation of personalized-dose medicines. Springer Science+Business Media, LLC, 2011 oral films nationallicence paediatric medicine nationallicence personalized medicines nationallicence salbutamol sulphate nationallicence thermal ink-jet nationallicence Buanz Asma School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX, London, UK aut Saunders Mark Kuecept Ltd., 16/17 Station Close, Potters Bar, EN6 1TL, Herts, UK aut Basit Abdul School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX, London, UK aut Gaisford Simon School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX, London, UK aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/10(2011-10-01), 2386-2392 0724-8741 28:10<2386 2011 28 11095 https://doi.org/10.1007/s11095-011-0450-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0450-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Buanz Asma School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX, London, UK aut NATIONALLICENCE 700 1- Saunders Mark Kuecept Ltd., 16/17 Station Close, Potters Bar, EN6 1TL, Herts, UK aut NATIONALLICENCE 700 1- Basit Abdul School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX, London, UK aut NATIONALLICENCE 700 1- Gaisford Simon School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX, London, UK aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/10(2011-10-01), 2386-2392 0724-8741 28:10<2386 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer