caa a22 4500 445313420 CHVBK 20180317142638.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s11095-010-0337-x doi (NATIONALLICENCE)springer-10.1007/s11095-010-0337-x Iontophoresis-Facilitated Delivery of Prednisolone through Throat Skin to the Trachea After Topical Application of its Succinate Salt [Elektronische Daten] [Hiroshi Ishii, Tsukasa Suzuki, Hiroaki Todo, Mitsuhiro Kamimura, Kenji Sugibayashi] ABSTRACT: Purpose: The possibility of direct delivery of steroids through the skin to the trachea and the effect of iontophoresis on delivery efficacy were evaluated after the application of an ionic steroidal prodrug, prednisolone sodium succinate (PS-Na), to the throat skin. Methods: Fluorescein sodium salt (FL-Na) and PS-Na were applied as model compounds at a concentration of 1% in pH7.4 phosphate-buffered saline to the throat skin of hairless rats, and constant current-cathodal iontophoresis (0.4mA/cm2) was performed for 8 or 10h. Results: In vitro permeation experiment involving cathodal iontophoresis through excised hairless rat abdominal skin revealed 30- and 10-times higher levels of skin permeation of PS and its active drug, prednisolone (P), than those induced without iontophoresis. In vivo iontophoresis treatment of the rat's throat skin produced 2.6-, 1.6- and 12-times higher FL, PS and P concentrations, respectively, in the trachea than those observed without iontophoresis. Conclusion: The present results suggest the usefulness of topical application of the ionic steroidal prodrugs onto throat skin followed by iontophoresis treatment for directly delivering the steroid to the trachea. Springer Science+Business Media, LLC, 2010 direct delivery nationallicence iontophoresis nationallicence skin permeation nationallicence steroidal prodrug nationallicence trachea nationallicence Ishii Hiroshi Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, 350-0295, Saitama, Japan aut Suzuki Tsukasa Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, 350-0295, Saitama, Japan aut Todo Hiroaki Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, 350-0295, Saitama, Japan aut Kamimura Mitsuhiro National Hospital Organization Disaster Medical Center, 3256 Midori, Tachikawa, 190-0014, Tokyo, Japan aut Sugibayashi Kenji Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, 350-0295, Saitama, Japan aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/4(2011-04-01), 839-847 0724-8741 28:4<839 2011 28 11095 https://doi.org/10.1007/s11095-010-0337-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-010-0337-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ishii Hiroshi Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, 350-0295, Saitama, Japan aut NATIONALLICENCE 700 1- Suzuki Tsukasa Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, 350-0295, Saitama, Japan aut NATIONALLICENCE 700 1- Todo Hiroaki Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, 350-0295, Saitama, Japan aut NATIONALLICENCE 700 1- Kamimura Mitsuhiro National Hospital Organization Disaster Medical Center, 3256 Midori, Tachikawa, 190-0014, Tokyo, Japan aut NATIONALLICENCE 700 1- Sugibayashi Kenji Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, 350-0295, Saitama, Japan aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/4(2011-04-01), 839-847 0724-8741 28:4<839 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer