caa a22 4500 445313617 CHVBK 20180317142638.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s11095-011-0417-6 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0417-6 Effect of Formulation- and Administration-Related Variables on Deposition Pattern of Nasal Spray Pumps Evaluated Using a Nasal Cast [Elektronische Daten] [Vipra Kundoor, Richard Dalby] ABSTRACT: Purpose: To systematically evaluate the effect of formulation- and administration-related variables on nasal spray deposition using a nasal cast. Methods: Deposition pattern was assessed by uniformly coating a transparent nose model with Sar-Gel®, which changes from white to purple on contact with water. Sprays were subsequently discharged into the cast, which was then digitally photographed. Images were quantified using Adobe® Photoshop. The effects of formulation viscosity (which influences droplet size), simulated administration techniques (head orientation, spray administration angle, spray nozzle insertion depth), spray pump design and metering volume on nasal deposition pattern were investigated. Results: There was a significant decrease in the deposition area associated with sprays of increasing viscosity. This appeared to be mediated by an increase in droplet size and a narrowing of the spray plume. Administration techniques and nasal spray pump design also had a significant effect on the deposition pattern. Conclusions: This simple color-based method provides quantitative estimates of the effects that different formulation and administration variables may have on the nasal deposition area, and provides a rational basis on which manufacturers of nasal sprays can base their patient instructions or post approval changes when it is impractical to optimize these using a clinical study. Springer Science+Business Media, LLC, 2011 deposition pattern nationallicence droplet size nationallicence formulation nationallicence nasal spray nationallicence spray pump design nationallicence viscosity nationallicence Kundoor Vipra Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Baltimore, Maryland, USA aut Dalby Richard Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Baltimore, Maryland, USA aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/8(2011-08-01), 1895-1904 0724-8741 28:8<1895 2011 28 11095 https://doi.org/10.1007/s11095-011-0417-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0417-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kundoor Vipra Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Baltimore, Maryland, USA aut NATIONALLICENCE 700 1- Dalby Richard Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Baltimore, Maryland, USA aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/8(2011-08-01), 1895-1904 0724-8741 28:8<1895 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer