caa a22 4500 44531365X CHVBK 20180317142638.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s11095-010-0360-y doi (NATIONALLICENCE)springer-10.1007/s11095-010-0360-y Intratumoral Drug Delivery with Nanoparticulate Carriers [Elektronische Daten] [Hillary Holback, Yoon Yeo] ABSTRACT: Stiff extracellular matrix, elevated interstitial fluid pressure, and the affinity for the tumor cells in the peripheral region of a solid tumor mass have long been recognized as significant barriers to diffusion of small-molecular-weight drugs and antibodies. However, their impacts on nanoparticle-based drug delivery have begun to receive due attention only recently. This article reviews biological features of many solid tumors that influence transport of drugs and nanoparticles and properties of nanoparticles relevant to their intratumoral transport, studied in various tumor models. We also discuss several experimental approaches employed to date for enhancement of intratumoral nanoparticle penetration. The impact of nanoparticle distribution on the effectiveness of chemotherapy remains to be investigated and should be considered in the design of new nanoparticulate drug carriers. Springer Science+Business Media, LLC, 2011 extracellular matrix nationallicence intratumoral distribution nationallicence interstitial fluid pressure nationallicence nanoparticles nationallicence solid tumors nationallicence Holback Hillary Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, 47907, West Lafayette, Indiana, USA aut Yeo Yoon Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, 47907, West Lafayette, Indiana, USA aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/8(2011-08-01), 1819-1830 0724-8741 28:8<1819 2011 28 11095 https://doi.org/10.1007/s11095-010-0360-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-010-0360-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holback Hillary Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, 47907, West Lafayette, Indiana, USA aut NATIONALLICENCE 700 1- Yeo Yoon Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, 47907, West Lafayette, Indiana, USA aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/8(2011-08-01), 1819-1830 0724-8741 28:8<1819 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer