caa a22 4500 445313692 CHVBK 20180317142639.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s11095-011-0486-6 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0486-6 Finding Promiscuous Old Drugs for New Uses [Elektronische Daten] [Sean Ekins, Antony Williams] ABSTRACT: From research published in the last sixyears we have identified 34 studies that have screened libraries of FDA-approved drugs against various whole cell or target assays. These studies have each identified one or more compounds with a suggested new bioactivity that had not been described previously. We now show that 13 of these drugs were active against more than one additional disease, thereby suggesting a degree of promiscuity. We also show that following compilation of all the studies, 109 molecules were identified by screening in vitro. These molecules appear to be statistically more hydrophobic with a higher molecular weight and AlogP than orphan-designated products with at least one marketing approval for a common disease indication or one marketing approval for a rare disease from the FDA's rare disease research database. Capturing these in vitro data on old drugs for new uses will be important for potential reuse and analysis by others to repurpose or reposition these or other existing drugs. We have created databases which can be searched by the public and envisage that these can be updated as more studies are published. Springer Science+Business Media, LLC, 2011 cheminformatics nationallicence HTS nationallicence old drugs nationallicence repositioning nationallicence repurposing nationallicence Ekins Sean Collaborations in Chemistry, 601 Runnymede Avenue, 19046, Jenkintown, Pennsylvania, USA aut Williams Antony Royal Society of Chemistry, 904 Tamaras Circle, 27587, Wake Forest, North Carolina, USA aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/8(2011-08-01), 1785-1791 0724-8741 28:8<1785 2011 28 11095 https://doi.org/10.1007/s11095-011-0486-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0486-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ekins Sean Collaborations in Chemistry, 601 Runnymede Avenue, 19046, Jenkintown, Pennsylvania, USA aut NATIONALLICENCE 700 1- Williams Antony Royal Society of Chemistry, 904 Tamaras Circle, 27587, Wake Forest, North Carolina, USA aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/8(2011-08-01), 1785-1791 0724-8741 28:8<1785 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer