caa a22 4500 445313781 CHVBK 20180317142639.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s11095-010-0314-4 doi (NATIONALLICENCE)springer-10.1007/s11095-010-0314-4 Progress Towards a Needle-Free Hepatitis B Vaccine [Elektronische Daten] [Filipa Lebre, Gerrit Borchard, Maria de Lima, Olga Borges] ABSTRACT: Hepatitis B virus (HBV) infection is a worldwide public health problem. Vaccination is the most efficient way to prevent hepatitis B. Despite the success of the currently available vaccine, there is a clear need for the development of new generation of HBV vaccines. Needle-free immunization is an attractive approach for mass immunization campaigns, since avoiding the use of needles reduces the risk of needle-borne diseases and prevents needle-stick injuries and pain, thus augmenting patient compliance and eliminating the need for trained medical personnel. Moreover, this kind of immunization was shown to induce good systemic as well as mucosal immunological responses, which is important for the creation of both a prophylactic and therapeutic vaccine. In order to produce a better, safer, more efficient and more suitable vaccine, adjuvants have been used. In this article, several adjuvants tested over the years for their potential to help create a needle-free vaccine against HBV are reviewed. Springer Science+Business Media, LLC, 2010 adjuvant nationallicence hepatitis B antigen nationallicence needle-free vaccine nationallicence Lebre Filipa Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal aut Borchard Gerrit School of Pharmaceutical Sciences, University of Geneva 30, Quai Ernest Ansermet 30, 1211, Geneva, Switzerland aut de Lima Maria Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal aut Borges Olga Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/5(2011-05-01), 986-1012 0724-8741 28:5<986 2011 28 11095 https://doi.org/10.1007/s11095-010-0314-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-010-0314-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lebre Filipa Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal aut NATIONALLICENCE 700 1- Borchard Gerrit School of Pharmaceutical Sciences, University of Geneva 30, Quai Ernest Ansermet 30, 1211, Geneva, Switzerland aut NATIONALLICENCE 700 1- de Lima Maria Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal aut NATIONALLICENCE 700 1- Borges Olga Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/5(2011-05-01), 986-1012 0724-8741 28:5<986 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer