caa a22 4500 445313897 CHVBK 20180317142639.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s11095-010-0356-7 doi (NATIONALLICENCE)springer-10.1007/s11095-010-0356-7 Contribution of Saccadic Motion to Intravitreal Drug Transport: Theoretical Analysis [Elektronische Daten] [Ram Balachandran, Victor Barocas] ABSTRACT: Purpose: The vitreous humor liquefies with age and readily sloshes during eye motion. The objective was to develop a computational model to determine the effect of sloshing on intravitreal drug transport for transscleral and intra-vitreal drug sources at various locations Methods: A finite element model based on a telescopic implicit envelope tracking scheme was developed to model drug dispersion. Flow velocities due to saccadic oscillations were solved for and were used to simulate drug dispersion. Results: Saccades induced a three-dimensional flow field that indicates intense drug dispersion in the vitreous. Model results showed that the time scale for transport decreased for the sloshing vitreous when compared to static vitreous. Macular concentrations for the sloshing vitreous were found be much higher than that for the static vitreous. For low viscosities the position of the intravitreal source did not have a big impact on drug distribution. Conclusion: Model results show that care should be taken when extrapolating animal data, which are mostly done on intact vitreous, to old patients whose vitreous might be a liquid. The decrease in drug transport time scales and changes in localized concentrations should be considered when deciding on treatment modalities and dosing strategies. Springer Science+Business Media, LLC, 2011 age-related macular degeneration nationallicence transscleral drug delivery nationallicence vitrectomy nationallicence vitreous liquefaction nationallicence Balachandran Ram Department of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota, USA aut Barocas Victor Department of Biomedical Engineering, University of Minnesota, 7-105 Nils Hasselmo Hall, 312 Church Street SE, 55455, Minneapolis, Minnesota, USA aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/5(2011-05-01), 1049-1064 0724-8741 28:5<1049 2011 28 11095 https://doi.org/10.1007/s11095-010-0356-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-010-0356-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Balachandran Ram Department of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota, USA aut NATIONALLICENCE 700 1- Barocas Victor Department of Biomedical Engineering, University of Minnesota, 7-105 Nils Hasselmo Hall, 312 Church Street SE, 55455, Minneapolis, Minnesota, USA aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/5(2011-05-01), 1049-1064 0724-8741 28:5<1049 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer