caa a22 4500 445313943 CHVBK 20180317142639.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s11095-010-0357-6 doi (NATIONALLICENCE)springer-10.1007/s11095-010-0357-6 Magnetic Resonance Imaging and Image Analysis for Assessment of HPMC Matrix Tablets Structural Evolution in USP Apparatus 4 [Elektronische Daten] [Piotr Kulinowski, Przemysław Dorożyński, Anna Młynarczyk, Władysław Węglarz] ABSTRACT: Purpose: The purpose of the study was to present a methodology for the processing of Magnetic Resonance Imaging (MRI) data for the quantification of the dosage form matrix evolution during drug dissolution. The results of the study were verified by comparison with other approaches presented in literature. Methods: A commercially available, HPMC-based quetiapine fumarate tablet was studied with a 4.7T MR system. Imaging was performed inside an MRI probe-head coupled with a flow-through cell for 12h in circulating water. The images were segmented into three regions using threshold-based segmentation algorithms due to trimodal structure of the image intensity histograms. Results: Temporal evolution of dry glassy, swollen glassy and gel regions was monitored. The characteristic features were observed: initial high expansion rate of the swollen glassy and gel layers due to initial water uptake, dry glassy core disappearance and maximum area of swollen glassy region at 4h, and subsequent gel layer thickness increase at the expense of swollen glassy layer. Conclusions: The temporal evolution of an HPMC-based tablet by means of noninvasive MRI integrated with USP Apparatus 4 was found to be consistent with both the theoretical model based on polymer disentanglement concentration and experimental VIS/FTIR studies. The Author(s), 2010 flow-through cell nationallicence HPMC nationallicence image analysis nationallicence magnetic resonance imaging nationallicence USP Apparatus 4 nationallicence CR : controlled release nationallicence FOV : field of view nationallicence FTIR : Fourier transform infrared nationallicence FTIR-ATR : Fourier transform infrared-attenuated total reflection nationallicence HPMC : Hydroxypropylmethylcellulose nationallicence MR : magnetic resonance nationallicence MRI : magnetic resonance imaging nationallicence TE : echo time nationallicence TR : repetition time nationallicence USP : United States Pharmacopoeia nationallicence VIS : macro-photography nationallicence Kulinowski Piotr Department of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, ul. Radzikowskiego 152, 31-342, Kraków, Poland aut Dorożyński Przemysław Department of Pharmaceutical Technology and Biopharmaceutics Pharmaceutical Faculty, Jagiellonian University, ul. Medyczna 9, 30-688, Kraków, Poland aut Młynarczyk Anna Department of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, ul. Radzikowskiego 152, 31-342, Kraków, Poland aut Węglarz Władysław Department of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, ul. Radzikowskiego 152, 31-342, Kraków, Poland aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/5(2011-05-01), 1065-1073 0724-8741 28:5<1065 2011 28 11095 https://doi.org/10.1007/s11095-010-0357-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-010-0357-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kulinowski Piotr Department of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, ul. Radzikowskiego 152, 31-342, Kraków, Poland aut NATIONALLICENCE 700 1- Dorożyński Przemysław Department of Pharmaceutical Technology and Biopharmaceutics Pharmaceutical Faculty, Jagiellonian University, ul. Medyczna 9, 30-688, Kraków, Poland aut NATIONALLICENCE 700 1- Młynarczyk Anna Department of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, ul. Radzikowskiego 152, 31-342, Kraków, Poland aut NATIONALLICENCE 700 1- Węglarz Władysław Department of Magnetic Resonance Imaging, Institute of Nuclear Physics Polish Academy of Sciences, ul. Radzikowskiego 152, 31-342, Kraków, Poland aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/5(2011-05-01), 1065-1073 0724-8741 28:5<1065 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer