caa a22 4500 445314133 CHVBK 20180317142640.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s11095-010-0241-4 doi (NATIONALLICENCE)springer-10.1007/s11095-010-0241-4 Nanoparticle Delivery Systems in Cancer Vaccines [Elektronische Daten] [Yogita Krishnamachari, Sean Geary, Caitlin Lemke, Aliasger Salem] ABSTRACT: Therapeutic strategies that involve the manipulation of the host's immune system are gaining momentum in cancer research. Antigen-loaded nanocarriers are capable of being actively taken up by antigen-presenting cells (APCs) and have shown promising potential in cancer immunotherapy by initiating a strong immunostimulatory cascade that results in potent antigen-specific immune responses against the cancer. Such carrier systems offer versatility in that they can simultaneously co-deliver adjuvants with the antigens to enhance APC activation and maturation. Furthermore, modifying the surface properties of these nanocarriers affords active targeting properties to APCs and/or enhanced accumulation in solid tumors. Here, we review some recent advances in these colloidal and particulate nanoscale systems designed for cancer immunotherapy and the potential for these systems to translate into clinical cancer vaccines. Springer Science+Business Media, LLC, 2010 cancer immunotherapy nationallicence colloidal nanocarriers nationallicence liposomes nationallicence polymeric nanoparticles nationallicence tumor targeting nationallicence Krishnamachari Yogita Department of Pharmaceutical Sciences & Experimental Therapeutics College of Pharmacy, University of Iowa, 52242, Iowa City, Iowa, USA aut Geary Sean Department of Pharmaceutical Sciences & Experimental Therapeutics College of Pharmacy, University of Iowa, 52242, Iowa City, Iowa, USA aut Lemke Caitlin Department of Pharmaceutical Sciences & Experimental Therapeutics College of Pharmacy, University of Iowa, 52242, Iowa City, Iowa, USA aut Salem Aliasger Department of Pharmaceutical Sciences & Experimental Therapeutics College of Pharmacy, University of Iowa, 52242, Iowa City, Iowa, USA aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/2(2011-02-01), 215-236 0724-8741 28:2<215 2011 28 11095 https://doi.org/10.1007/s11095-010-0241-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-010-0241-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Krishnamachari Yogita Department of Pharmaceutical Sciences & Experimental Therapeutics College of Pharmacy, University of Iowa, 52242, Iowa City, Iowa, USA aut NATIONALLICENCE 700 1- Geary Sean Department of Pharmaceutical Sciences & Experimental Therapeutics College of Pharmacy, University of Iowa, 52242, Iowa City, Iowa, USA aut NATIONALLICENCE 700 1- Lemke Caitlin Department of Pharmaceutical Sciences & Experimental Therapeutics College of Pharmacy, University of Iowa, 52242, Iowa City, Iowa, USA aut NATIONALLICENCE 700 1- Salem Aliasger Department of Pharmaceutical Sciences & Experimental Therapeutics College of Pharmacy, University of Iowa, 52242, Iowa City, Iowa, USA aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/2(2011-02-01), 215-236 0724-8741 28:2<215 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer