caa a22 4500 445314214 CHVBK 20180317142640.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s11095-010-0281-9 doi (NATIONALLICENCE)springer-10.1007/s11095-010-0281-9 Influence of Temperature on Solvent-Mediated Anhydrate-to-Hydrate Transformation Kinetics [Elektronische Daten] [Haiyan Qu, Tommy Munk, Claus Cornett, Jian Wu, Johan Bøtker, Lars Christensen, Jukka Rantanen, Fang Tian] ABSTRACT: Purpose: To achieve an in-depth understanding of the underlying mechanism of the acceleration or deceleration effect of temperature on solvent-mediated anhydrate-to-hydrate phase transformation. Methods: The effect of temperature on the phase transformation rate and onset time of two model compounds was investigated using in situ Raman spectroscopy. The thermodynamic driving force of the phase transformation (e.g. supersaturation) at different temperatures was determined by measuring the solubility of the anhydrate and the hydrate. Results: Both acceleration and deceleration effects of temperature on the phase transformation were observed. The mechanism of these temperature effects was studied by exploring the influence of temperature on supersaturation level and crystallization kinetics. Increasing temperature usually leads to accelerated phase transformation kinetics, but it simultaneously decreases supersaturation, which has the opposite effect on the kinetics of the phase transformation. The overall effect of temperature on the phase transformation is therefore determined by the combined effects of supersaturation and temperature on the nucleation and crystal growth kinetics of the hydrate. Conclusions: By differentiating and comparing the effects of temperature and supersaturation on the anhydrate-to-hydrate phase transformation, a deeper understanding of the underlying principle of the acceleration and deceleration effects of temperature on the phase transformation has been achieved. Springer Science+Business Media, LLC, 2010 anhydrate-to-hydrate nationallicence crystallization nationallicence phase transformation nationallicence supersaturation nationallicence Qu Haiyan Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut Munk Tommy Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut Cornett Claus Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut Wu Jian Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut Bøtker Johan Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut Christensen Lars Institute of Chemical Engineering Biotechnology and Environmental Technology, Faculty of Engineering, University of Southern Denmark, Niels Bohrs Allé 1, 5230, Odense M, Denmark aut Rantanen Jukka Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut Tian Fang Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/2(2011-02-01), 364-373 0724-8741 28:2<364 2011 28 11095 https://doi.org/10.1007/s11095-010-0281-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-010-0281-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Qu Haiyan Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Munk Tommy Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Cornett Claus Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Wu Jian Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Bøtker Johan Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Christensen Lars Institute of Chemical Engineering Biotechnology and Environmental Technology, Faculty of Engineering, University of Southern Denmark, Niels Bohrs Allé 1, 5230, Odense M, Denmark aut NATIONALLICENCE 700 1- Rantanen Jukka Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Tian Fang Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/2(2011-02-01), 364-373 0724-8741 28:2<364 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer