caa a22 4500 445314230 CHVBK 20180317142640.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s11095-011-0584-5 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0584-5 Mitochondrial Metabolism Inhibitors for Cancer Therapy [Elektronische Daten] [Emma Ramsay, Philip Hogg, Pierre Dilda] ABSTRACT: Cancer cells catabolise nutrients in a different way than healthy cells. Healthy cells mainly rely on oxidative phosphorylation, while cancer cells employ aerobic glycolysis. Glucose is the main nutrient catabolised by healthy cells, while cancer cells often depend on catabolism of both glucose and glutamine. A key organelle involved in this altered metabolism is mitochondria. Mitochondria coordinate the catabolism of glucose and glutamine across the cancer cell. Targeting mitochondrial metabolism in cancer cells has potential for the treatment of this disease. Perhaps the most promising target is the hexokinase-voltage dependent anion channel-adenine nucleotide translocase complex that spans the outer- and inner-mitochondrial membranes. This complex links glycolysis, oxidative phosphorylation and mitochondrial-mediated apoptosis in cancer cells. This review discusses cancer cell mitochondrial metabolism and the small molecule inhibitors of this metabolism that are in pre-clinical or clinical development. Springer Science+Business Media, LLC, 2011 adenine nucleotide translocase nationallicence cancer nationallicence hexokinase nationallicence metabolism nationallicence mitochondria nationallicence alpha-TOS : alpha-tocopheryl succinate nationallicence ANT : adenine nucleotide translocase nationallicence ATP : adenosine triphosphate nationallicence CAO : 4-(N-(S-cysteinylacetyl)amino) phenylarsonous acid nationallicence FADH2 : flavin adenine dinucleotide nationallicence FH : fumarate hydratase nationallicence GCAO : 4-(N-(S-cysteinylglycylacetyl)amino) phenylarsonous acid nationallicence G6P : glucose-6-phosphate nationallicence GLUT : glucose transporter nationallicence GPT : glutamate pyruvate transaminase nationallicence GSAO : 4-(N-(S-glutathionylacetyl)amino)phenylarsonous acid nationallicence HIF1 : hypoxia inducible factor 1 nationallicence IDH : isocitrate dehydrogenase nationallicence NADH : nicotinamide adenine dinucleotide (reduced) nationallicence NADPH : nicotinamide adenine dinucleotide phosphate (reduced) nationallicence NSCLC : non-small-cell lung carcinoma nationallicence PENAO : 4-(N-(S-penicillaminylacetyl)amino)phenylarsonous acid nationallicence PDH : pyruvate dehydrogenase nationallicence PDHK : pyruvate dehydrogenase kinase nationallicence SDH : succinate dehydrogenase nationallicence TCA : tricarboxylic acid cycle nationallicence VDAC : voltage dependent anion channel nationallicence Ramsay Emma Prince of Wales Clinical School, Lowy Cancer Research Centre, University of New South Wales, 2052, Sydney, NSW, Australia aut Hogg Philip Prince of Wales Clinical School, Lowy Cancer Research Centre, University of New South Wales, 2052, Sydney, NSW, Australia aut Dilda Pierre Prince of Wales Clinical School, Lowy Cancer Research Centre, University of New South Wales, 2052, Sydney, NSW, Australia aut Pharmaceutical Research Springer US; http://www.springer-ny.com 28/11(2011-11-01), 2731-2744 0724-8741 28:11<2731 2011 28 11095 https://doi.org/10.1007/s11095-011-0584-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0584-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ramsay Emma Prince of Wales Clinical School, Lowy Cancer Research Centre, University of New South Wales, 2052, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Hogg Philip Prince of Wales Clinical School, Lowy Cancer Research Centre, University of New South Wales, 2052, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Dilda Pierre Prince of Wales Clinical School, Lowy Cancer Research Centre, University of New South Wales, 2052, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/11(2011-11-01), 2731-2744 0724-8741 28:11<2731 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer