caa a22 4500 445314435 CHVBK 20180317142641.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s11095-011-0556-9 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0556-9 Weissig Volkmar Midwestern University College of Pharmacy Glendale, Glendale, Arizona, USA aut From Serendipity to Mitochondria-Targeted Nanocarriers [Elektronische Daten] [Volkmar Weissig] ABSTRACT: This review illustrates how a random observation at the laboratory bench has helped pave the way towards the development of organelle-targeted pharmaceutical nanocarriers. A fortuitous discovery in the mid 1990s involving the self-assembly of a molecule, known to accumulate inside mitochondria, has lead to the development of subcellular nanocarriers suited for the selective delivery of biologically active molecules to mitochondria inside living mammalian cells. Applications for mitochondria-specific drug and DNA delivery are described, the current state-of-the-art of mitochondrial drug targeting technology is reviewed, and its future perspectives are discussed. Springer Science+Business Media, LLC, 2011 apoptosis nationallicence dequalinium nationallicence DQAsomes nationallicence gene therapy nationallicence mitochondria nationallicence mitochondria-specific liposomes nationallicence mitochondria-targeted nanocarriers nationallicence STPP liposomes nationallicence triphenylphosphonium nationallicence Pharmaceutical Research Springer US; http://www.springer-ny.com 28/11(2011-11-01), 2657-2668 0724-8741 28:11<2657 2011 28 11095 https://doi.org/10.1007/s11095-011-0556-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0556-9 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Weissig Volkmar Midwestern University College of Pharmacy Glendale, Glendale, Arizona, USA aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/11(2011-11-01), 2657-2668 0724-8741 28:11<2657 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer