caa a22 4500 44531446X CHVBK 20180317142641.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s11095-011-0587-2 doi (NATIONALLICENCE)springer-10.1007/s11095-011-0587-2 Edeas Marvin Institute For Antioxidants Applications International Society of Antioxidants in Nutrition and Health (ISANH) Antioxidants Task Force, 15 rue de la paix, 75002, Paris, France aut Strategies to Target Mitochondria and Oxidative Stress by Antioxidants: Key Points and Perspectives [Elektronische Daten] [Marvin Edeas] ABSTRACT: For several decades, many antioxidants studies have emphasized the marked disparity between the beneficial effect of the antioxidants shown in preclinical studies and their inability to show beneficial effects in clinical trials. Besides, it is not uncommon to find highly contradictory clinical results, which may explain why consumers are less enthusiastic for antioxidant uses. This perspective article aims to highlights the critical role of Reactive Oxygen Species (ROS) and antioxidants, the potential mechanisms that might account for these discrepancies in clinical trials and some strategies to target oxidative stress and mitochondria by antioxidants. We need urgently to set up standard methods to evaluate antioxidants and oxidative stress in human and in particular at mitochondria level. The determination of what the basal level of ROS is in normal human may be used to identify pathologic ROS levels in patients and ultimately guide antioxidants treatment. Springer Science+Business Media, LLC, 2011 antioxidant nationallicence mitochondria nationallicence oxidative stress nationallicence standardization methods nationallicence Pharmaceutical Research Springer US; http://www.springer-ny.com 28/11(2011-11-01), 2771-2779 0724-8741 28:11<2771 2011 28 11095 https://doi.org/10.1007/s11095-011-0587-2 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11095-011-0587-2 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Edeas Marvin Institute For Antioxidants Applications International Society of Antioxidants in Nutrition and Health (ISANH) Antioxidants Task Force, 15 rue de la paix, 75002, Paris, France aut NATIONALLICENCE 773 0- Pharmaceutical Research Springer US; http://www.springer-ny.com 28/11(2011-11-01), 2771-2779 0724-8741 28:11<2771 2011 28 11095 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer