caa a22 4500 445314494 CHVBK 20180317142641.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10552-010-9679-2 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9679-2 Reduction in arsenic intake from water has different impacts on lung cancer and bladder cancer in an arseniasis endemic area in Taiwan [Elektronische Daten] [Che-Chun Su, Jia-Ling Lu, Kuo-Yang Tsai, Ie-Bin Lian] Background: Excessive arsenic intake has a detrimental effect on human health, as reflected in an increase in cancer incidence. In an area on the southwest coast of Taiwan, arsenic intake from well water since the 1920s had caused an exceptionally high mortality from cancer. Municipal water has become available to people living in the arseniasis endemic area since the early 1970s. This study explored the impacts of reduction in arsenic intake from water on lung cancer and bladder cancer in the arseniasis endemic area in Taiwan. Methods: Chart records of 23,013 patients diagnosed with bladder cancer and 93,633 patients with lung cancer from 1979 to 2003 were retrieved from the Taiwan Cancer Registry Center. We used the age-period-cohort model to study the changes in the incidence of lung cancer and bladder cancer in the arseniasis endemic area and the rest of Taiwan. Results: Three decades after municipal water supply to the arseniasis and black foot disease endemic area (BFDEA), we saw a marked decrease in the incidence of both bladder cancer and lung cancer in the area, especially for those in the later cohorts. The relative risk (RR) of getting a bladder cancer for people living in BFDEA when compared with those in the rest of Taiwan has dropped from 20 for the early cohorts to 5 for the late cohorts. As to lung cancer, the RR has decreased from 8 to between 1.5 and 2. Conclusion: Reduction in arsenic intake from water has a positive impact on the incidence of both lung and bladder cancer; however, while RR for lung cancer has dropped to below 2, RR for bladder cancer remained at around 5. The difference may be because (1) there are other risk factors beside the well-water intake or (2) bladder cancer may have longer latency period for excessive arsenic exposure than lung cancer. More studies are required to understand the causes behind the difference in RR for these two types of cancer. Springer Science+Business Media B.V., 2010 Arsenic exposure nationallicence Bladder cancer nationallicence Lung cancer nationallicence APC model nationallicence Su Che-Chun Department of Internal Medicine, Changhua Christian Hospital, 135, Nan-Hsiao Street, 500, Changhua, Taiwan aut Lu Jia-Ling Graduate Institute of Statistics and Information Science, National Changhua University of Education, 500, Changhua, Taiwan aut Tsai Kuo-Yang Department of Oral and Maxillofacial Surgery, Changhua Christian Hospital, 135, Nan-Hsiao Street, 500, Changhua, Taiwan aut Lian Ie-Bin Graduate Institute of Statistics and Information Science, National Changhua University of Education, 500, Changhua, Taiwan aut Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 101-108 0957-5243 22:1<101 2011 22 10552 https://doi.org/10.1007/s10552-010-9679-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9679-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Su Che-Chun Department of Internal Medicine, Changhua Christian Hospital, 135, Nan-Hsiao Street, 500, Changhua, Taiwan aut NATIONALLICENCE 700 1- Lu Jia-Ling Graduate Institute of Statistics and Information Science, National Changhua University of Education, 500, Changhua, Taiwan aut NATIONALLICENCE 700 1- Tsai Kuo-Yang Department of Oral and Maxillofacial Surgery, Changhua Christian Hospital, 135, Nan-Hsiao Street, 500, Changhua, Taiwan aut NATIONALLICENCE 700 1- Lian Ie-Bin Graduate Institute of Statistics and Information Science, National Changhua University of Education, 500, Changhua, Taiwan aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 101-108 0957-5243 22:1<101 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer