caa a22 4500 445314516 CHVBK 20180317142641.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10552-010-9669-4 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9669-4 Groundwater uranium and cancer incidence in South Carolina [Elektronische Daten] [Sara Wagner, James Burch, Matteo Bottai, Robin Puett, Dwayne Porter, Susan Bolick-Aldrich, Tom Temples, Rebecca Wilkerson, John Vena, James Hébert] Objective: This ecologic study tested the hypothesis that census tracts with elevated groundwater uranium and more frequent groundwater use have increased cancer incidence. Methods: Data sources included: incident total, leukemia, prostate, breast, colorectal, lung, kidney, and bladder cancers (1996-2005, SC Central Cancer Registry); demographic and groundwater use (1990 US Census); and groundwater uranium concentrations (n=4,600, from existing federal and state databases). Kriging was used to predict average uranium concentrations within tracts. The relationship between uranium and standardized cancer incidence ratios was modeled among tracts with substantial groundwater use via linear or semiparametric regression, with and without stratification by the proportion of African Americans in each area. Results: A total of 134,685 cancer cases were evaluated. Tracts with ≥50% groundwater use and uranium concentrations in the upper quartile had increased risks for colorectal, breast, kidney, prostate, and total cancer compared to referent tracts. Some of these relationships were more likely to be observed among tracts populated primarily by African Americans. Conclusion: SC regions with elevated groundwater uranium and more groundwater use may have an increased incidence of certain cancers, although additional research is needed since the design precluded adjustment for race or other predictive factors at the individual level. Springer Science+Business Media B.V., 2010 Cancer nationallicence GIS nationallicence Uranium nationallicence Groundwater nationallicence Disparities nationallicence AA : African American nationallicence CI : Confidence interval nationallicence DHEC : Department of Health and Environmental Control nationallicence EA : European American nationallicence GIS : Geographic information system nationallicence MCL : Maximum contaminant level nationallicence NAWQA : National Water-Quality Assessment nationallicence NURE : National Uranium Resource Evaluation nationallicence RDL : Reference dose level nationallicence SC : South Carolina nationallicence SCCCR : South Carolina Central Cancer Registry nationallicence SIR : Standardized incidence ratio nationallicence USGS : United States Geological Survey nationallicence Wagner Sara College of Public Health, Department of Epidemiology and Biostatistics, Paul D. Coverdell Center for Biomedical and Health Sciences, University of Georgia, 500 D.W. Brooks Drive, 30602-7396, Athens, GA, USA aut Burch James Arnold School of Public Health, Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA aut Bottai Matteo Arnold School of Public Health, Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA aut Puett Robin Arnold School of Public Health, Department of Environmental Health Sciences, University of South Carolina, Columbia, SC, USA aut Porter Dwayne Arnold School of Public Health, Department of Environmental Health Sciences, University of South Carolina, Columbia, SC, USA aut Bolick-Aldrich Susan South Carolina Central Cancer Registry, South Carolina Department of Health and Environmental Control, Columbia, SC, USA aut Temples Tom College of Engineering & Science, Department of Environmental Engineering and Earth Sciences, Clemson University, Clemson, SC, USA aut Wilkerson Rebecca Public Health Statistics and Information Services, South Carolina Department of Health and Environmental Control, Columbia, SC, USA aut Vena John College of Public Health, Department of Epidemiology and Biostatistics, Paul D. Coverdell Center for Biomedical and Health Sciences, University of Georgia, 500 D.W. Brooks Drive, 30602-7396, Athens, GA, USA aut Hébert James Arnold School of Public Health, Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA aut Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 41-50 0957-5243 22:1<41 2011 22 10552 https://doi.org/10.1007/s10552-010-9669-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9669-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wagner Sara College of Public Health, Department of Epidemiology and Biostatistics, Paul D. Coverdell Center for Biomedical and Health Sciences, University of Georgia, 500 D.W. Brooks Drive, 30602-7396, Athens, GA, USA aut NATIONALLICENCE 700 1- Burch James Arnold School of Public Health, Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA aut NATIONALLICENCE 700 1- Bottai Matteo Arnold School of Public Health, Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA aut NATIONALLICENCE 700 1- Puett Robin Arnold School of Public Health, Department of Environmental Health Sciences, University of South Carolina, Columbia, SC, USA aut NATIONALLICENCE 700 1- Porter Dwayne Arnold School of Public Health, Department of Environmental Health Sciences, University of South Carolina, Columbia, SC, USA aut NATIONALLICENCE 700 1- Bolick-Aldrich Susan South Carolina Central Cancer Registry, South Carolina Department of Health and Environmental Control, Columbia, SC, USA aut NATIONALLICENCE 700 1- Temples Tom College of Engineering & Science, Department of Environmental Engineering and Earth Sciences, Clemson University, Clemson, SC, USA aut NATIONALLICENCE 700 1- Wilkerson Rebecca Public Health Statistics and Information Services, South Carolina Department of Health and Environmental Control, Columbia, SC, USA aut NATIONALLICENCE 700 1- Vena John College of Public Health, Department of Epidemiology and Biostatistics, Paul D. Coverdell Center for Biomedical and Health Sciences, University of Georgia, 500 D.W. Brooks Drive, 30602-7396, Athens, GA, USA aut NATIONALLICENCE 700 1- Hébert James Arnold School of Public Health, Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 41-50 0957-5243 22:1<41 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer