caa a22 4500 445314559 CHVBK 20180317142641.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10552-010-9675-6 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9675-6 Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12 [Elektronische Daten] [Seo-yun Tong, Mi Kim, Jae Lee, Jong Lee, Sang Choi, Simonetta Friso, Eun-Seop Song, Kwang Lee, Jung Lee] Objective: We evaluated associations between folate, vitamin B12, and the methylenetetrahydrofolate reductase (MTHFR) gene, and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: This multicenter case-control study enrolled 927 Korean women (440 controls, 165 patients with CIN 1, 167 patients with CIN 2/3, and 155 patients with cervical cancer, aged 20-75years). Results: Patients with cervical cancer had significantly lower median serum folate and vitamin B12 concentrations vs. controls. Higher serum folate was significantly associated with lower cervical cancer risk (p for linear trend=0.0058) with a trend for a lower CIN risk after multivariate adjustment. Low folate and the MTHFR 677 C>T variant were associated with a higher risk for CIN2/3 and cervical cancer vs. wild-type or heterozygous genotypes with high folate [OR, 2.39 (1.18-4.85) and 3.19 (1.43-7.13)]. Low vitamin B12 and the MTHFR 677 C>T variant also were associated with a higher risk for CIN 2/3 and cervical cancers [OR, 2.52 (1.17-5.42) and 2.40 (1-5.73)] vs. wild-type or heterozygous status with high vitamin levels. Conclusion: Serum folate concentration is inversely associated with the risk of cervical cancer, and the MTHFR variant genotype may increase CIN and cervical cancer risk in women with low folate or vitamin B12 status. Springer Science+Business Media B.V., 2010 Folate nationallicence Vitamin B12 nationallicence Genetic polymorphisms nationallicence Methylenetetrahydrofolate reductase nationallicence Cervical intraepithelial neoplasia nationallicence Cervical cancer nationallicence Tong Seo-yun Department of Obstetrics and Gynecology, East-West Neo Medical Center, Kyunghee University College of Medicine, Seoul, Korea aut Kim Mi Cancer Epidemiology Branch, National Cancer Center, 111, Jungbalsan-ro, Madu-dong, Ilsandong-gu, 411-769, Goyang-si, Gyeonggi-do, Korea aut Lee Jae College of Medicine, Korea University, Seoul, Korea aut Lee Jong Department of Obstetrics and Gynecology, East-West Neo Medical Center, Kyunghee University College of Medicine, Seoul, Korea aut Choi Sang Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA aut Friso Simonetta University of Verona School of Medicine, Verona, Italy aut Song Eun-Seop The Inha University, Incheon, Korea aut Lee Kwang Gil Medical Center, Gachon University of Medicine and Science, Inchon, Korea aut Lee Jung Ajou University School of Medicine, Suwon, Korea aut Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 63-72 0957-5243 22:1<63 2011 22 10552 https://doi.org/10.1007/s10552-010-9675-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9675-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tong Seo-yun Department of Obstetrics and Gynecology, East-West Neo Medical Center, Kyunghee University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Mi Cancer Epidemiology Branch, National Cancer Center, 111, Jungbalsan-ro, Madu-dong, Ilsandong-gu, 411-769, Goyang-si, Gyeonggi-do, Korea aut NATIONALLICENCE 700 1- Lee Jae College of Medicine, Korea University, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Jong Department of Obstetrics and Gynecology, East-West Neo Medical Center, Kyunghee University College of Medicine, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Sang Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA aut NATIONALLICENCE 700 1- Friso Simonetta University of Verona School of Medicine, Verona, Italy aut NATIONALLICENCE 700 1- Song Eun-Seop The Inha University, Incheon, Korea aut NATIONALLICENCE 700 1- Lee Kwang Gil Medical Center, Gachon University of Medicine and Science, Inchon, Korea aut NATIONALLICENCE 700 1- Lee Jung Ajou University School of Medicine, Suwon, Korea aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 63-72 0957-5243 22:1<63 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer