caa a22 4500 445314575 CHVBK 20180317142641.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10552-010-9659-6 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9659-6 Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer [Elektronische Daten] [Stefan de Vogel, Kim Wouters, Ralph Gottschalk, Frederik van Schooten, Anton de Goeij, Adriaan de Bruïne, R. Goldbohm, Piet van den Brandt, Manon van Engeland, Matty Weijenberg] Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). Among 609 CRC cases and 1,663 subcohort members of the Netherlands Cohort Study on diet and cancer (n=120,852), we estimated CRC risk according to methyl donor intake across genotypes of folate metabolizing enzymes and methyltransferases. Although diet-gene interactions were not statistically significant, methionine intake was inversely associated with CRC among subjects having both common rs2424913 and rs406193 DNMT3B C>T genotypes (highest versus lowest tertile: RR=0.44; p trend=0.05). Likewise, vitamin B2 was modestly inversely associated among individuals with the MTHFR c.665CC (rs1801133) genotype (RR=0.66; p trend=0.08), but with a significant reduced risk when≤1 rare allele occurred in the combination of folate metabolizing enzymes MTHFR, MTRR and MTR (RR=0.30; p trend=0.005). Folate or vitamin B6 were neither inversely associated with CRC nor was methyl donor intake associated with the CpG island methylator phenotype (CIMP). Despite the absence of heterogeneity across genotypes, might an effect of methyl donors on CRC be more pronounced among individuals carrying common variants of folate metabolizing enzymes or DNA methyltransferases. Combining genotypes may assist to reveal diet associations with CRC, possibly because rare variants of related genes may collectively affect specific metabolic pathways or enzymatic functions. The Author(s), 2010 Methyl donors nationallicence Diet-gene interactions nationallicence Promoter hypermethylation nationallicence CRC nationallicence de Vogel Stefan Institute for Public Health and Primary Health Care, University of Bergen, 7804, 5020, Bergen, Norway aut Wouters Kim GROW—School for Oncology and Developmental Biology, Department of Pathology, Maastricht University, Maastricht, The Netherlands aut Gottschalk Ralph Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands aut van Schooten Frederik Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands aut de Goeij Anton GROW—School for Oncology and Developmental Biology, Department of Pathology, Maastricht University, Maastricht, The Netherlands aut de Bruïne Adriaan GROW—School for Oncology and Developmental Biology, Department of Pathology, Maastricht University, Maastricht, The Netherlands aut Goldbohm R. Department of Prevention and Health, TNO Quality of Life, Leiden, The Netherlands aut van den Brandt Piet GROW—School for Oncology and Developmental Biology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands aut van Engeland Manon GROW—School for Oncology and Developmental Biology, Department of Pathology, Maastricht University, Maastricht, The Netherlands aut Weijenberg Matty GROW—School for Oncology and Developmental Biology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands aut Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 1-12 0957-5243 22:1<1 2011 22 10552 https://doi.org/10.1007/s10552-010-9659-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9659-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Vogel Stefan Institute for Public Health and Primary Health Care, University of Bergen, 7804, 5020, Bergen, Norway aut NATIONALLICENCE 700 1- Wouters Kim GROW—School for Oncology and Developmental Biology, Department of Pathology, Maastricht University, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Gottschalk Ralph Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- van Schooten Frederik Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- de Goeij Anton GROW—School for Oncology and Developmental Biology, Department of Pathology, Maastricht University, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- de Bruïne Adriaan GROW—School for Oncology and Developmental Biology, Department of Pathology, Maastricht University, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Goldbohm R. Department of Prevention and Health, TNO Quality of Life, Leiden, The Netherlands aut NATIONALLICENCE 700 1- van den Brandt Piet GROW—School for Oncology and Developmental Biology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- van Engeland Manon GROW—School for Oncology and Developmental Biology, Department of Pathology, Maastricht University, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Weijenberg Matty GROW—School for Oncology and Developmental Biology, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 1-12 0957-5243 22:1<1 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer