caa a22 4500 445314591 CHVBK 20180317142641.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10552-010-9680-9 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9680-9 Intake of heterocyclic aromatic amines and the risk of prostate cancer in the EPIC-Heidelberg cohort [Elektronische Daten] [Anja Sander, Jakob Linseisen, Sabine Rohrmann] Background: Heterocyclic amines (HCA) are positively associated with prostate cancer risk in animal models. Because of mostly inconsistent results of epidemiological studies, we examined the association between intake of HCA and prostate cancer risk. Methods: In the EPIC-Heidelberg cohort, detailed information on diet, anthropometry, and lifestyle was assessed between 1994 and 1998. Dietary HCA intake was estimated using information on meat consumption, cooking methods, and preferred degree of browning. During 104,195 person-years of follow-up, 337 incident cases of prostate cancer (123 advanced cases) were identified among 9,578 men with valid dietary information. Multivariate Cox proportional hazards regression was used to examine the association between intake of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 2-amino-3,4,8-dimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and prostate cancer. Results: Men in the highest quartiles of PhIP, MeIQx, and DiMeIQx intake, respectively, had no increased risk of prostate cancer compared with men in the lowest quartiles (HR=0.89, 95% CI 0.66-1.22 [PhIP]; 1.06, 0.77-1.45 [MeIQx]; 0.98, 0.72-1.34 [DiMeIQx]). There were no associations between HCA intake and advanced prostate cancer or between high consumption of strongly browned meat and prostate cancer. Discussion: Our data do not support the hypothesis that HCA intake as consumed in a regular diet is a risk factor for prostate cancer. Springer Science+Business Media B.V., 2010 Heterocyclic aromatic amines nationallicence Prostate cancer nationallicence Cohort study nationallicence Sander Anja Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut Linseisen Jakob Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut Rohrmann Sabine Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 109-114 0957-5243 22:1<109 2011 22 10552 https://doi.org/10.1007/s10552-010-9680-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9680-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sander Anja Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 700 1- Linseisen Jakob Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 700 1- Rohrmann Sabine Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 109-114 0957-5243 22:1<109 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 28546194X BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer