caa a22 4500 445314605 CHVBK 20180317142641.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10552-010-9665-8 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9665-8 Soft drinks, sweetened beverages and risk of pancreatic cancer [Elektronische Daten] [Silvano Gallus, Federica Turati, Alessandra Tavani, Jerry Polesel, Renato Talamini, Silvia Franceschi, Carlo La Vecchia] Soft drinks usually contain sugar and caffeine that might influence pancreatic carcinogenesis. We considered the association between carbonated drink consumption and pancreatic cancer risk in an Italian case-control study conducted in 1991-2008 on 326 pancreatic cancer cases and 652 matched controls. We also combined the results from all the studies on soft drinks or sweetened beverages and pancreatic cancer published before June 2010, using a meta-analytic approach. In the case-control study, compared with non-drinkers, the multivariate odds ratio was 1.02 (95% confidence interval, CI, 0.72-1.44) for carbonated drink consumers and 0.89 (95% CI 0.53-1.50) for regular consumers (at least one drink/day). Besides our study, from the literature search, we identified 4 other case-control (1,919 cases) and 6 cohort studies (2,367 cases). The pooled relative risks (RR) for soft drink consumers vs. non-consumers were 0.97 (95% CI 0.81-1.16) for case-control, 1.05 (95% CI 0.94-1.17) for cohort, and 1.02 (95% CI 0.93-1.12) for all studies. The pooled RRs for heavy drinkers were 1.08 (95% CI 0.73-1.60) for case-control, 1.21 (95% CI 0.90-1.63) for cohort, and 1.16 (95% CI 0.93-1.45) for all studies. In conclusion, soft drink consumption is not materially related to pancreatic cancer risk. Springer Science+Business Media B.V., 2010 Soft drink nationallicence Pancreatic cancer nationallicence Case-control study nationallicence Meta-analysis nationallicence Risk factor nationallicence Gallus Silvano Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche "Mario Negri”, 20156, Milan, Italy aut Turati Federica Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche "Mario Negri”, 20156, Milan, Italy aut Tavani Alessandra Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche "Mario Negri”, 20156, Milan, Italy aut Polesel Jerry Unità di Epidemiologia e Biostatistica, IRCCS Centro di Riferimento Oncologico, 33081, Aviano, PN, Italy aut Talamini Renato Unità di Epidemiologia e Biostatistica, IRCCS Centro di Riferimento Oncologico, 33081, Aviano, PN, Italy aut Franceschi Silvia Infections and Cancer Epidemiology Group, International Agency for Cancer Research, 69372, Lyon CEDEX 08, France aut La Vecchia Carlo Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche "Mario Negri”, 20156, Milan, Italy aut Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 33-39 0957-5243 22:1<33 2011 22 10552 https://doi.org/10.1007/s10552-010-9665-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9665-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gallus Silvano Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche "Mario Negri”, 20156, Milan, Italy aut NATIONALLICENCE 700 1- Turati Federica Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche "Mario Negri”, 20156, Milan, Italy aut NATIONALLICENCE 700 1- Tavani Alessandra Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche "Mario Negri”, 20156, Milan, Italy aut NATIONALLICENCE 700 1- Polesel Jerry Unità di Epidemiologia e Biostatistica, IRCCS Centro di Riferimento Oncologico, 33081, Aviano, PN, Italy aut NATIONALLICENCE 700 1- Talamini Renato Unità di Epidemiologia e Biostatistica, IRCCS Centro di Riferimento Oncologico, 33081, Aviano, PN, Italy aut NATIONALLICENCE 700 1- Franceschi Silvia Infections and Cancer Epidemiology Group, International Agency for Cancer Research, 69372, Lyon CEDEX 08, France aut NATIONALLICENCE 700 1- La Vecchia Carlo Dipartimento di Epidemiologia, Istituto di Ricerche Farmacologiche "Mario Negri”, 20156, Milan, Italy aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 33-39 0957-5243 22:1<33 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer