caa a22 4500 445314613 CHVBK 20180317142641.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10552-010-9684-5 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9684-5 Nutritional supplements, COX - 2 and IGF - 1 expression in men on active surveillance for prostate cancer [Elektronische Daten] [June Chan, Vivian Weinberg, Mark Magbanua, Eduardo Sosa, Jeffry Simko, Katsuto Shinohara, Scot Federman, Mike Mattie, Millie Hughes-Fulford, Christopher Haqq, Peter Carroll] Background: Nutritional factors are associated with reduced risk of prostate cancer progression, yet mechanisms remain unclear. We examined the effects of lycopene and fish oil supplements versus placebo on the normal prostate microenvironment, among men pursuing active surveillance for low-burden prostate cancer. We hypothesized that lycopene or fish oil supplements would down-regulate insulin-like growth factor-1 (IGF-1) and cyclooxygenase 2 (COX-2) gene expression, respectively, reflecting putative proliferation (IGF-1) and inflammatory (COX-2) pathways relevant to carcinogenesis. Methods: We conducted a 3-month randomized, double-blinded, clinical trial comparing prostate tissue gene expression profiles (assessed by qRT-PCR) among men with favorable-risk prostate cancer receiving either 30mg/day lycopene, 3g/day fish oil (including 1,098mg eicosapentaenoic and 549mg docosahexaenoic fatty acids) or placebo. Results: Among 69 men (22 assigned to lycopene, 21 to fish, and 26 to placebo), there was no difference in the change from baseline to the 3 months in IGF-1 expression level between the placebo and lycopene arms (p=0.93) nor in COX-2 expression between the placebo and fish arms (p=0.99). Conclusion: Compared to placebo, 3-month intervention with lycopene or fish oil did not significantly change IGF-1 and COX-2 gene expression in the normal prostate microenvironment in men with low-burden prostate cancer. Further analysis of global gene expression profiles may shed light on the bioactivity and relevance of these nutrients in prostate cancer. The Author(s), 2010 Prostate cancer nationallicence Active surveillance nationallicence Fish oil nationallicence Lycopene nationallicence Randomized clinical trial nationallicence Chan June Department of Urology, University of California San Francisco (UCSF), MC 3110, 1450 3rd Street, PO Box 589001, 94158-9001, San Francisco, CA, USA aut Weinberg Vivian Helen Diller Family Comprehensive Cancer Center Biostatistics Core, UCSF, San Francisco, USA aut Magbanua Mark Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, USA aut Sosa Eduardo Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, USA aut Simko Jeffry Department of Urology, University of California San Francisco (UCSF), MC 3110, 1450 3rd Street, PO Box 589001, 94158-9001, San Francisco, CA, USA aut Shinohara Katsuto Department of Urology, University of California San Francisco (UCSF), MC 3110, 1450 3rd Street, PO Box 589001, 94158-9001, San Francisco, CA, USA aut Federman Scot Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, USA aut Mattie Mike Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, USA aut Hughes-Fulford Millie Department of Urology, University of California San Francisco (UCSF), MC 3110, 1450 3rd Street, PO Box 589001, 94158-9001, San Francisco, CA, USA aut Haqq Christopher Department of Urology, University of California San Francisco (UCSF), MC 3110, 1450 3rd Street, PO Box 589001, 94158-9001, San Francisco, CA, USA aut Carroll Peter Department of Urology, University of California San Francisco (UCSF), MC 3110, 1450 3rd Street, PO Box 589001, 94158-9001, San Francisco, CA, USA aut Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 141-150 0957-5243 22:1<141 2011 22 10552 https://doi.org/10.1007/s10552-010-9684-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9684-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chan June Department of Urology, University of California San Francisco (UCSF), MC 3110, 1450 3rd Street, PO Box 589001, 94158-9001, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Weinberg Vivian Helen Diller Family Comprehensive Cancer Center Biostatistics Core, UCSF, San Francisco, USA aut NATIONALLICENCE 700 1- Magbanua Mark Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, USA aut NATIONALLICENCE 700 1- Sosa Eduardo Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, USA aut NATIONALLICENCE 700 1- Simko Jeffry Department of Urology, University of California San Francisco (UCSF), MC 3110, 1450 3rd Street, PO Box 589001, 94158-9001, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Shinohara Katsuto Department of Urology, University of California San Francisco (UCSF), MC 3110, 1450 3rd Street, PO Box 589001, 94158-9001, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Federman Scot Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, USA aut NATIONALLICENCE 700 1- Mattie Mike Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, USA aut NATIONALLICENCE 700 1- Hughes-Fulford Millie Department of Urology, University of California San Francisco (UCSF), MC 3110, 1450 3rd Street, PO Box 589001, 94158-9001, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Haqq Christopher Department of Urology, University of California San Francisco (UCSF), MC 3110, 1450 3rd Street, PO Box 589001, 94158-9001, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Carroll Peter Department of Urology, University of California San Francisco (UCSF), MC 3110, 1450 3rd Street, PO Box 589001, 94158-9001, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 141-150 0957-5243 22:1<141 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer