caa a22 4500 44531463X CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10552-010-9676-5 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9676-5 Tobacco smoking as a risk factor of bronchioloalveolar carcinoma of the lung: pooled analysis of seven case-control studies in the International Lung Cancer Consortium (ILCCO) [Elektronische Daten] [Paolo Boffetta, Vijayvel Jayaprakash, Ping Yang, Kofi Asomaning, Joshua Muscat, Ann Schwartz, Zuo-Feng Zhang, Loic Le Marchand, Michele Cote, Shawn Stoddard, Hal Morgenstern, Rayjean Hung, David Christiani] Background: The International Lung Cancer Consortium (ILCCO) was established in 2004, based on the collaboration of research groups leading large molecular epidemiology studies of lung cancer that are ongoing or have been recently completed. This framework offered the opportunity to investigate the role of tobacco smoking in the development of bronchioloalveolar carcinoma (BAC), a rare form of lung cancer. Methods: Our pooled data comprised seven case-control studies from the United States, with detailed information on tobacco smoking and histology, which contributed 799 cases of BAC and 15,859 controls. We estimated the odds ratio of BAC for tobacco smoking, using never smokers as a referent category, after adjustment for age, sex, race, and study center. Results: The odds ratio of BAC for ever smoking was 2.47 (95% confidence interval [CI] 2.08, 2.93); the risk increased linearly with duration, amount, and cumulative cigarette smoking and persisted long after smoking cessation. The proportion of BAC cases attributable to smoking was 0.47 (95% CI 0.39, 0.54). Conclusions: This analysis provides a precise estimate of the risk of BAC for tobacco smoking. The Author(s), 2010 Lung cancer nationallicence Bronchioloalveolar carcinoma nationallicence Tobacco smoking nationallicence Boffetta Paolo The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA aut Jayaprakash Vijayvel Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY, USA aut Yang Ping Division of Epidemiology and Cancer Center, Mayo Clinic, Rochester, MN, USA aut Asomaning Kofi Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA aut Muscat Joshua Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA aut Schwartz Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA aut Zhang Zuo-Feng Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA aut Le Marchand Loic Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA aut Cote Michele Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA aut Stoddard Shawn Division of Epidemiology and Cancer Center, Mayo Clinic, Rochester, MN, USA aut Morgenstern Hal Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA aut Hung Rayjean Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, ON, Canada aut Christiani David Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA aut Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 73-79 0957-5243 22:1<73 2011 22 10552 https://doi.org/10.1007/s10552-010-9676-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9676-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boffetta Paolo The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, USA aut NATIONALLICENCE 700 1- Jayaprakash Vijayvel Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Yang Ping Division of Epidemiology and Cancer Center, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Asomaning Kofi Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA aut NATIONALLICENCE 700 1- Muscat Joshua Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA aut NATIONALLICENCE 700 1- Schwartz Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA aut NATIONALLICENCE 700 1- Zhang Zuo-Feng Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Le Marchand Loic Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA aut NATIONALLICENCE 700 1- Cote Michele Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA aut NATIONALLICENCE 700 1- Stoddard Shawn Division of Epidemiology and Cancer Center, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Morgenstern Hal Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Hung Rayjean Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Christiani David Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 73-79 0957-5243 22:1<73 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer