caa a22 4500 445314648 CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10552-010-9671-x doi (NATIONALLICENCE)springer-10.1007/s10552-010-9671-x Dietary glycemic index, glycemic load, insulin index, fiber and whole-grain intake in relation to risk of prostate cancer [Elektronische Daten] [K. Nimptsch, S. Kenfield, M. Jensen, M. Stampfer, M. Franz, L. Sampson, J. Brand-Miller, W. Willett, E. Giovannucci] Objective: Insulin may play a role in prostate cancer tumorigenesis. Postprandial blood glucose and insulin responses of foods depend importantly on the carbohydrate quality and quantity, represented by glycemic index (GI), glycemic load (GL), fiber and whole-grain content, but are also influenced by intake of protein and other characteristics. The recently developed insulin index (II) quantifies the postprandial insulin secretion, also taking into account these additional characteristics. Methods: We investigated the association between dietary GI, GL, II, fiber, and whole grains and risk of total prostate cancer (n=5,112) and subgroups of prostate cancer as defined by stage or grade in 49,934 male participants of the Health Professionals Follow-up Study. Multivariate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards regression. Results: Dietary GI, GL, II, or fiber was not associated with risk of total or subgroups of prostate cancer. We observed a positive association between dietary intake of whole grains and total prostate cancer (HR highest versus lowest quintile 1.13, 95% CI 1.03-1.24), which was attenuated after restriction to PSA-screened participants (HR 1.03, 95% CI 0.91-1.17). Conclusions: These results suggest that long-term exposure to a diet with a high insulin response does not affect prostate cancer incidence. Springer Science+Business Media B.V., 2010 Glycemic index nationallicence Glycemic load nationallicence Insulin index nationallicence Fiber nationallicence Whole grains nationallicence Prostate cancer nationallicence Nimptsch K. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut Kenfield S. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut Jensen M. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut Stampfer M. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut Franz M. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut Sampson L. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut Brand-Miller J. Institute of Obesity, Nutrition, and Exercise, University of Sydney, Sydney, NSW, Australia aut Willett W. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut Giovannucci E. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 51-61 0957-5243 22:1<51 2011 22 10552 https://doi.org/10.1007/s10552-010-9671-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9671-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nimptsch K. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Kenfield S. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut NATIONALLICENCE 700 1- Jensen M. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Stampfer M. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Franz M. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Sampson L. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Brand-Miller J. Institute of Obesity, Nutrition, and Exercise, University of Sydney, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Willett W. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Giovannucci E. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Room 304, 02115, Boston, MA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 51-61 0957-5243 22:1<51 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer