caa a22 4500 445314656 CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10552-010-9677-4 doi (NATIONALLICENCE)springer-10.1007/s10552-010-9677-4 Physical activity and endogenous sex hormones in postmenopausal women: to what extent are observed associations confounded or modified by BMI? [Elektronische Daten] [Stefanie Liedtke, Martina Schmidt, Susen Becker, Rudolf Kaaks, Aida Zaineddin, Katharina Buck, Dieter Flesch-Janys, Jürgen Wahrendorf, Jenny Chang-Claude, Karen Steindorf] Objectives: To investigate associations between physical activity and endogenous sex hormones after menopause with a special focus on confounding and effect modification by body mass index (BMI). Methods: A cross-sectional study among 1,260 postmenopausal women was conducted. Generalized linear models were used to compare levels of total leisure-time physical activity, sports activities, bicycling, and walking with levels of sex hormones and sex-hormone-binding-globulin (SHBG). Results: Higher sports activity levels were significantly associated with lower levels of estrone and total and free testosterone in multivariate adjusted models. After additional adjustment for BMI, associations with estrone and free testosterone were attenuated; the association with total testosterone remained unchanged. No physical activity variable was significantly related to total and free estradiol, androstenedione, or SHBG. We did not observe effect modification by BMI. Conclusions: Sports activities may lead to lower levels of estrone and testosterone in postmenopausal women. While effects on estrone and free testosterone seem to be largely mediated by BMI, effects on total testosterone appear to be mainly independent of BMI. The BMI-independent effects on these hormones (especially on total testosterone) could at least partly explain why physical activity has been frequently reported to be preventive for postmenopausal breast cancer, even after accounting for BMI. Springer Science+Business Media B.V., 2010 Physical activity nationallicence Sports nationallicence Sex hormones nationallicence Postmenopausal women nationallicence Breast cancer nationallicence Liedtke Stefanie Unit of Environmental Epidemiology, German Cancer Research Center, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Schmidt Martina Unit of Environmental Epidemiology, German Cancer Research Center, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Becker Susen Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut Kaaks Rudolf Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut Zaineddin Aida Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut Buck Katharina Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut Flesch-Janys Dieter Department of Medical Biometry and Epidemiology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany aut Wahrendorf Jürgen Unit of Environmental Epidemiology, German Cancer Research Center, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Chang-Claude Jenny Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut Steindorf Karen Unit of Environmental Epidemiology, German Cancer Research Center, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 81-89 0957-5243 22:1<81 2011 22 10552 https://doi.org/10.1007/s10552-010-9677-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-010-9677-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liedtke Stefanie Unit of Environmental Epidemiology, German Cancer Research Center, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Schmidt Martina Unit of Environmental Epidemiology, German Cancer Research Center, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Becker Susen Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 700 1- Kaaks Rudolf Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 700 1- Zaineddin Aida Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 700 1- Buck Katharina Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 700 1- Flesch-Janys Dieter Department of Medical Biometry and Epidemiology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany aut NATIONALLICENCE 700 1- Wahrendorf Jürgen Unit of Environmental Epidemiology, German Cancer Research Center, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Chang-Claude Jenny Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 700 1- Steindorf Karen Unit of Environmental Epidemiology, German Cancer Research Center, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/1(2011-01-01), 81-89 0957-5243 22:1<81 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer