caa a22 4500 445314680 CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10552-011-9760-5 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9760-5 Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data [Elektronische Daten] [Brandon Pierce, Melissa Austin, Habibul Ahsan] Objective: To examine associations between recently identified common type 2 diabetes (T2D) susceptibility genetic variants and pancreatic cancer risk. Methods: Using data on individuals of European ancestry from the Cancer Genetic Markers of Susceptibility PanScan-I study (1,763 pancreatic cancer cases and 1,802 controls), we tested associations for 37 T2D susceptibility variants with pancreatic cancer risk. Associations with pancreatic cancer were also tested for three composite T2D susceptibility measures, incorporating data on all 37 variants, and for ten additional variants related to T2D-related phenotypes, including fasting glucose and beta-cell function. Results: Of the 37 T2D risk alleles, two showed nominally significant positive associations with pancreatic cancer risk (FTO rs8050136 per-allele OR=1.12; CI: 1.02-1.23; MTNR1B rs1387153 OR=1.11; CI: 1.00-1.23) and one showed an inverse association (BCL11A rs243021 OR=0.88; CI: 0.80-0.97). The composite T2D susceptibility measures were not associated with pancreatic cancer. The glucose-raising allele of MADD rs11039149 was associated with increased risk of pancreatic cancer (OR=1.14; CI: 1.03-1.27). Conclusions: Overall, these results do not provide strong evidence that common variants underling T2D or related phenotypes also affect pancreatic cancer risk; however, associations for FTO, MTNR1B, BCL11A, and MADD variants warrant further investigation in larger studies. Hypothesis-driven analyses of existing genome-wide genetic data can be cost-efficient and promising approaches for investigating genetic susceptibility to complex diseases. Springer Science+Business Media B.V., 2011 Pancreatic cancer nationallicence Type 2 diabetes nationallicence Risk score nationallicence Genome-wide association study nationallicence Pierce Brandon Department of Health Studies and Comprehensive Cancer Center, The University of Chicago, 5841 South Maryland Avenue, Suite N101, 60637, Chicago, IL, USA aut Austin Melissa Institute for Public Health Genetics and Department of Epidemiology, University of Washington, 98195, Seattle, WA, USA aut Ahsan Habibul Center for Cancer Epidemiology and Prevention, Department of Health Studies, The University of Chicago, 5841 South Maryland Avenue, Suite N101, 60637, Chicago, IL, USA aut Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 877-883 0957-5243 22:6<877 2011 22 10552 https://doi.org/10.1007/s10552-011-9760-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9760-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pierce Brandon Department of Health Studies and Comprehensive Cancer Center, The University of Chicago, 5841 South Maryland Avenue, Suite N101, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Austin Melissa Institute for Public Health Genetics and Department of Epidemiology, University of Washington, 98195, Seattle, WA, USA aut NATIONALLICENCE 700 1- Ahsan Habibul Center for Cancer Epidemiology and Prevention, Department of Health Studies, The University of Chicago, 5841 South Maryland Avenue, Suite N101, 60637, Chicago, IL, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 877-883 0957-5243 22:6<877 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer