caa a22 4500 445314699 CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10552-011-9763-2 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9763-2 Height at diagnosis and birth-weight as risk factors for osteosarcoma [Elektronische Daten] [Lisa Mirabello, Ruth Pfeiffer, Gwen Murphy, Najat Daw, Ana Patiño-Garcia, Rebecca Troisi, Robert Hoover, Chester Douglass, Joachim Schüz, Alan Craft, Sharon Savage] Objectives : Osteosarcoma typically occurs during puberty. Studies of the association between height and/or birth-weight and osteosarcoma are conflicting. Therefore, we conducted a large pooled analysis of height and birth-weight in osteosarcoma. Methods: Patient data from seven studies of height and three of birth-weight were obtained, resulting in 1,067 cases with height and 434 cases with birth-weight data. We compared cases to the 2000 US National Center for Health Statistics Growth Charts by simulating 1,000 age- and gender-matched controls per case. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for associations between height or birth-weight and risk of osteosarcoma for each study were estimated using logistic regression. All of the case data were combined for an aggregate analysis. Results: Compared to average birth-weight subjects (2,665-4,045g), individuals with high birth-weight (≥4,046g) had an increased osteosarcoma risk (OR 1.35, 95% CI 1.01-1.79). Taller than average (51st-89th percentile) and very tall individuals (≥90th percentile) had an increased risk of osteosarcoma (OR 1.35, 95% CI 1.18-1.54 and OR 2.60, 95% CI 2.19-3.07, respectively; P trend<0.0001). Conclusions: This is the largest analysis of height at diagnosis and birth-weight in relation to osteosarcoma. It suggests that rapid bone growth during puberty and in utero contributes to OS etiology. Springer Science+Business Media B.V. (outside the USA), 2011 Osteosarcoma nationallicence Height nationallicence Birth-weight nationallicence Meta-analysis nationallicence Epidemiology nationallicence Mirabello Lisa Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Pfeiffer Ruth Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Murphy Gwen Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Daw Najat Department of Oncology, St Jude Children's Research Hospital, and Department of Pediatrics, University of Tennessee, College of Medicine, Memphis, TN, USA aut Patiño-Garcia Ana Department of PediatricsLaboratory of Pediatrics, Pediatric Oncology Unit, University Clinic of Navarra, Pamplona, Spain aut Troisi Rebecca Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Hoover Robert Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Douglass Chester Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut Schüz Joachim Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark aut Craft Alan Department of Child Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK aut Savage Sharon Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 899-908 0957-5243 22:6<899 2011 22 10552 https://doi.org/10.1007/s10552-011-9763-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9763-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mirabello Lisa Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Pfeiffer Ruth Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Murphy Gwen Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Daw Najat Department of Oncology, St Jude Children's Research Hospital, and Department of Pediatrics, University of Tennessee, College of Medicine, Memphis, TN, USA aut NATIONALLICENCE 700 1- Patiño-Garcia Ana Department of PediatricsLaboratory of Pediatrics, Pediatric Oncology Unit, University Clinic of Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Troisi Rebecca Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Hoover Robert Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Douglass Chester Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut NATIONALLICENCE 700 1- Schüz Joachim Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Craft Alan Department of Child Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK aut NATIONALLICENCE 700 1- Savage Sharon Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 899-908 0957-5243 22:6<899 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer