caa a22 4500 445314710 CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10552-011-9762-3 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9762-3 Early-life sun exposure and risk of melanoma before age 40years [Elektronische Daten] [Anne Cust, Mark Jenkins, Chris Goumas, Bruce Armstrong, Helen Schmid, Joanne Aitken, Graham Giles, Richard Kefford, John Hopper, Graham Mann] Objective: To examine associations between early-life sun exposure and risk of invasive cutaneous melanoma diagnosed between ages 18 and 39years. Methods: Data were analysed from 606 cases and 481 controls from the Australian Melanoma Family Study, a population-based, case-control-family study. Self- and parent-reported sun exposure was collected by interview. Odds ratios (OR) were estimated using unconditional logistic regression, adjusted for potential confounders. Results: Self-reported childhood total sun exposure was not associated with melanoma overall, but was positively associated with melanoma diagnosed at 18-29years of age (OR for highest vs. lowest quartile: 3.21, 95% confidence intervals (CI) 1.38-7.44; P trend 0.02; P interaction by age group 0.09). Analyses restricted to participants whose self-reported sun exposure was concordant with that recalled by their parents gave an OR for the highest versus lowest tertile of childhood total sun exposure of 2.28 (95% CI 1.03-5.04; P trend 0.05), and for any versus no severe childhood sunburn of 2.36 (95% CI 1.05-5.31). The association of self-reported severe sunburn with melanoma was evident only in people who tended to tan rather than burn and in people who had few nevi. Conclusion: The association of early-life sun exposure with early-onset melanoma is influenced by host factors. Springer Science+Business Media B.V., 2011 Melanoma nationallicence Sun exposure nationallicence Early-onset nationallicence Sunburn nationallicence UV : Ultraviolet nationallicence Cust Anne Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia aut Jenkins Mark Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia aut Goumas Chris Cancer Epidemiology and Services Research (CESR), Sydney School of Public Health, Sydney Medical School, The University of Sydney, QEII Building D02, 2006, Sydney, NSW, Australia aut Armstrong Bruce Cancer Epidemiology and Services Research (CESR), Sydney School of Public Health, Sydney Medical School, The University of Sydney, QEII Building D02, 2006, Sydney, NSW, Australia aut Schmid Helen Westmead Institute for Cancer Research, Millennium Institute and Melanoma Institute Australia, University of Sydney at Westmead, Sydney, NSW, Australia aut Aitken Joanne Viertel Centre for Research in Cancer Control, Cancer Council Queensland, Spring Hill, Brisbane, QLD, Australia aut Giles Graham Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia aut Kefford Richard Westmead Institute for Cancer Research, Millennium Institute and Melanoma Institute Australia, University of Sydney at Westmead, Sydney, NSW, Australia aut Hopper John Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia aut Mann Graham Westmead Institute for Cancer Research, Millennium Institute and Melanoma Institute Australia, University of Sydney at Westmead, Sydney, NSW, Australia aut Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 885-897 0957-5243 22:6<885 2011 22 10552 https://doi.org/10.1007/s10552-011-9762-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9762-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cust Anne Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia aut NATIONALLICENCE 700 1- Jenkins Mark Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia aut NATIONALLICENCE 700 1- Goumas Chris Cancer Epidemiology and Services Research (CESR), Sydney School of Public Health, Sydney Medical School, The University of Sydney, QEII Building D02, 2006, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Armstrong Bruce Cancer Epidemiology and Services Research (CESR), Sydney School of Public Health, Sydney Medical School, The University of Sydney, QEII Building D02, 2006, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Schmid Helen Westmead Institute for Cancer Research, Millennium Institute and Melanoma Institute Australia, University of Sydney at Westmead, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Aitken Joanne Viertel Centre for Research in Cancer Control, Cancer Council Queensland, Spring Hill, Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Giles Graham Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia aut NATIONALLICENCE 700 1- Kefford Richard Westmead Institute for Cancer Research, Millennium Institute and Melanoma Institute Australia, University of Sydney at Westmead, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Hopper John Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia aut NATIONALLICENCE 700 1- Mann Graham Westmead Institute for Cancer Research, Millennium Institute and Melanoma Institute Australia, University of Sydney at Westmead, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 885-897 0957-5243 22:6<885 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer