caa a22 4500 445314729 CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10552-011-9766-z doi (NATIONALLICENCE)springer-10.1007/s10552-011-9766-z Cigarette smoking and the risk of incident and fatal melanoma in a large prospective cohort study [Elektronische Daten] [John DeLancey, Lindsay Hannan, Susan Gapstur, Michael Thun] Objective: Previous studies suggest that smoking may be inversely associated with risk of melanoma. We attempted to replicate this finding using data from the Cancer Prevention Study II (CPS-II) and CPS-II Nutrition cohort, two large prospective cohort studies of cancer mortality and incidence, respectively, with long-term follow-up. Methods: Cox proportional hazards regression analysis was used to examine the association between smoking status and risk of melanoma mortality and incidence among Caucasians in these cohorts. Analyses were adjusted by age, occupation, latitude and educational status. Results: The incidence rate of melanoma was lower in current than never smokers in both men [hazard ratio (HR): 0.70, 95% confidence interval (CI): (0.48-1.02)] and women [0.50 (0.30-0.83)]; incidence was not lower in former than in never smokers for either sex. The death rate from melanoma was lower in male current than never smokers [0.77 (0.62-0.94)], and in male and female former smokers [0.86 (0.73-1.01)] and [0.83 (0.65-1.06)], respectively. No trends in incidence or mortality were observed in male or female current smokers with years of smoking or cigarettes per day. Conclusions: This study provides limited support for the hypothesis that smoking reduces melanoma risk. The inconsistent results by smoking status and lack of clear dose-response relationships weaken the evidence for causality. Springer Science+Business Media B.V., 2011 Smoking nationallicence Melanoma nationallicence Cohort study nationallicence DeLancey John Department of Epidemiology Research, American Cancer Society, Atlanta, GA, USA aut Hannan Lindsay Department of Epidemiology Research, American Cancer Society, Atlanta, GA, USA aut Gapstur Susan Department of Epidemiology Research, American Cancer Society, Atlanta, GA, USA aut Thun Michael Department of Epidemiology Research, American Cancer Society, Atlanta, GA, USA aut Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 937-942 0957-5243 22:6<937 2011 22 10552 https://doi.org/10.1007/s10552-011-9766-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9766-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- DeLancey John Department of Epidemiology Research, American Cancer Society, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Hannan Lindsay Department of Epidemiology Research, American Cancer Society, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Gapstur Susan Department of Epidemiology Research, American Cancer Society, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Thun Michael Department of Epidemiology Research, American Cancer Society, Atlanta, GA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 937-942 0957-5243 22:6<937 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer