caa a22 4500 445314737 CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10552-011-9752-5 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9752-5 Association of serum 25-hydroxyvitamin D (25-OHD) concentrations with maternal sex steroids and IGF-1 hormones during pregnancy [Elektronische Daten] [Adetunji Toriola, Helja-Marja Surcel, Anika Husing, Kjell Grankvist, Hans-Ake Lakso, Helena Schock, Eva Lundin, Matti Lehtinen, Annekatrin Lukanova] Background: Vitamin D may influence circulating levels of sex steroid hormones in women during reproductive life, but associations in pregnant women have not been explored. Methods: Correlation and linear regression models were used to assess the association between sex steroids, (estradiol, progesterone, 17-hydroxyprogesterone, testosterone, and androstenedione), IGF-1, and serum 25-hydroxyvitamin D (25-OHD) concentrations during the first trimester of pregnancy in 106 cancer-free women from the Finnish Maternity Cohort. Results: There was no significant association of serum 25-OHD with any of the hormones measured. One-unit increase in serum 25-OHD concentration was associated with a non-significant 6% increase in estradiol concentrations. Multiparous women had higher levels of vitamin D (40.4 vs. 32.9nmol/L, p-value=0.01) than primiparous women. Conclusion: Our study does not support an association between maternal serum 25-OHD levels and sex steroids or IGF-I concentrations during the first trimester of pregnancy. Springer Science+Business Media B.V., 2011 Vitamin D nationallicence Estradiol nationallicence Progesterone nationallicence Testosterone nationallicence Androstenedione nationallicence IGF-1 nationallicence Sex steroids nationallicence Pregnancy nationallicence Toriola Adetunji National Institute for Health and Welfare, PL 310, 90101, Oulu, Finland aut Surcel Helja-Marja National Institute for Health and Welfare, PL 310, 90101, Oulu, Finland aut Husing Anika Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany aut Grankvist Kjell Department of Medical Biosciences, Umeå University, Umeå, Sweden aut Lakso Hans-Ake Department of Medical Biosciences, Umeå University, Umeå, Sweden aut Schock Helena Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany aut Lundin Eva Department of Medical Biosciences, Umeå University, Umeå, Sweden aut Lehtinen Matti Tampere School of Public Health, University of Tampere, Tampere, Finland aut Lukanova Annekatrin Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany aut Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 925-928 0957-5243 22:6<925 2011 22 10552 https://doi.org/10.1007/s10552-011-9752-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9752-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Toriola Adetunji National Institute for Health and Welfare, PL 310, 90101, Oulu, Finland aut NATIONALLICENCE 700 1- Surcel Helja-Marja National Institute for Health and Welfare, PL 310, 90101, Oulu, Finland aut NATIONALLICENCE 700 1- Husing Anika Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany aut NATIONALLICENCE 700 1- Grankvist Kjell Department of Medical Biosciences, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Lakso Hans-Ake Department of Medical Biosciences, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Schock Helena Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany aut NATIONALLICENCE 700 1- Lundin Eva Department of Medical Biosciences, Umeå University, Umeå, Sweden aut NATIONALLICENCE 700 1- Lehtinen Matti Tampere School of Public Health, University of Tampere, Tampere, Finland aut NATIONALLICENCE 700 1- Lukanova Annekatrin Department of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 925-928 0957-5243 22:6<925 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer