caa a22 4500 445314753 CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10552-011-9754-3 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9754-3 Diabetes mellitus and increased risk of biliary tract cancer: systematic review and meta-analysis [Elektronische Daten] [Hong-Bo Ren, Tao Yu, Chao Liu, Yan-Qing Li] Objective: Epidemiological evidences indicate that diabetic individuals may have an increased risk of several cancers; however, the relationships between diabetes and risk of cancers of biliary tract or its subsites remain unclear. Methods: To provide a quantitative assessment of this relationship, we identified studies by a literature search of Medline (from 1 January 1966) and EMBASE (from 1 January 1974), through 31 July 2010, and by searching the reference lists of pertinent articles. Summary relative risks with corresponding 95% confidence intervals were calculated with a random-effect model. Results: Analysis of 21 studies (8 case-control and 13 cohort studies) found that diabetes was associated with an increased risk of biliary tract cancer, compared with no diabetes (summary RRs=1.43, 95% CI=1.18-1.72), with significant heterogeneity among studies (p=0.001). The positive association was also found between diabetes and risk of gallbladder cancer or extrahepatic cholangiocarcinoma, but not cancer of ampulla of Vater. No significant publication bias was found. Conclusion: These findings strongly support the link between diabetes and increased risk of cancer of biliary tract and its subsites: gallbladder cancer or extrahepatic cholangiocarcinoma, but not cancer of ampulla of Vater. Springer Science+Business Media B.V., 2011 Biliary tract cancer nationallicence Diabetes mellitus nationallicence Relative risk nationallicence Systematic review nationallicence Meta-analysis nationallicence BTC : Biliary tract cancer nationallicence GBC : Gallbladder cancer nationallicence ECC : Extrahepatic cholangiocarcinoma nationallicence AVC : Cancer of ampulla of Vater nationallicence DM : Diabetes mellitus nationallicence AORs : Adjusted odds ratios nationallicence CI : Confidence intervals nationallicence IGFs : Insulin-like growth factors nationallicence SIR/SMR : Standardized incidence/mortality ratio nationallicence HR : Hazard ratio nationallicence Ren Hong-Bo Department of Gastroenterology, Shandong University Qilu Hospital, 107 Wenhua xi Road, 250012, Jinan, Shandong Province, China aut Yu Tao Department of Gastroenterology, Shandong University Qilu Hospital, 107 Wenhua xi Road, 250012, Jinan, Shandong Province, China aut Liu Chao Department of Gastroenterology, Shandong University Qilu Hospital, 107 Wenhua xi Road, 250012, Jinan, Shandong Province, China aut Li Yan-Qing Department of Gastroenterology, Shandong University Qilu Hospital, 107 Wenhua xi Road, 250012, Jinan, Shandong Province, China aut Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 837-847 0957-5243 22:6<837 2011 22 10552 https://doi.org/10.1007/s10552-011-9754-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9754-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ren Hong-Bo Department of Gastroenterology, Shandong University Qilu Hospital, 107 Wenhua xi Road, 250012, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Yu Tao Department of Gastroenterology, Shandong University Qilu Hospital, 107 Wenhua xi Road, 250012, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Liu Chao Department of Gastroenterology, Shandong University Qilu Hospital, 107 Wenhua xi Road, 250012, Jinan, Shandong Province, China aut NATIONALLICENCE 700 1- Li Yan-Qing Department of Gastroenterology, Shandong University Qilu Hospital, 107 Wenhua xi Road, 250012, Jinan, Shandong Province, China aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 837-847 0957-5243 22:6<837 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer