caa a22 4500 44531477X CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10552-011-9755-2 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9755-2 Spatial clustering of leukemia and type 1 diabetes in children in Denmark [Elektronische Daten] [Sven Schmiedel, Geoffrey Jacquez, Maria Blettner, Joachim Schüz] It has been proposed that type 1 diabetes (T1D) and leukemia in children may cluster in space and time due to common spatially mediated etiologies. We investigated this hypothesis and clustering of both diseases separately in Danish children aged 0-14years, using 1,168 leukemia cases diagnosed in the period 1980-2006, 2,443 T1D cases diagnosed 1996-2006, and population-based controls matched on age, gender, and time of diagnosis. Residential histories from birth to diagnosis were collected. For leukemia in ages 0-14years, we found no evidence of clustering; we did find spatial clustering at time of diagnosis for children aged 2-6years with acute lymphoblastic leukemia (ALL) (observed/expected [95% confidence interval]: 1.35 [1.15-1.54]). T1D cases showed clustering at birth for ages 0-14years; for ages 0-4years at diagnosis, and when the residential history was accounted for. T1D cases clustered near leukemia cases particularly in the age group 2-6years at diagnosis. Leukemia and T1D in this age group thus may share etiological factors mediated by geographic location. This suggests common environmental risk factors, with exposure to infections as first possible candidate, geographically localized exposure to agents that compromise development and/or response of the immune system being a second, and chance being a third. Springer Science+Business Media B.V., 2011 Clustering nationallicence Leukemia nationallicence Diabetes nationallicence Children nationallicence Denmark nationallicence Schmiedel Sven Institute for Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100, Copenhagen, Denmark aut Jacquez Geoffrey BioMedware, Inc., 3526 W Liberty, Suite 100, 48103, Ann Arbor, MI, USA aut Blettner Maria Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre of the Johannes Gutenberg University Mainz, Obere Zahlbacher Straße 69, 55131, Mainz, Germany aut Schüz Joachim International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France aut Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 849-857 0957-5243 22:6<849 2011 22 10552 https://doi.org/10.1007/s10552-011-9755-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9755-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schmiedel Sven Institute for Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Jacquez Geoffrey BioMedware, Inc., 3526 W Liberty, Suite 100, 48103, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Blettner Maria Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre of the Johannes Gutenberg University Mainz, Obere Zahlbacher Straße 69, 55131, Mainz, Germany aut NATIONALLICENCE 700 1- Schüz Joachim International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas, 69372, Lyon Cedex 08, France aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 849-857 0957-5243 22:6<849 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer