caa a22 4500 445314796 CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10552-011-9761-4 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9761-4 Physical activity and cancer prevention: a systematic review of clinical trials [Elektronische Daten] [Brooke Winzer, David Whiteman, Marina Reeves, Jennifer Paratz] Background: Physically active individuals have lower rates of many cancers and improved cancer outcomes. Controlled exercise trials measuring putative biomarkers of cancer risk are being conducted to further understand the role of exercise in cancer etiology and progression. We aimed to systematically review the effect of exercise on various biomarkers. Methods: A comprehensive search strategy identified 353 publications from January 1980 to August 2010. We included those clinical trials of exercise measuring biomarkers following minimum 4-week intervention among cancer survivors or people with one or more cancer risk factors. Two reviewers abstracted data and assessed quality independently. Effect sizes and 95% confidence intervals were estimated. Results: Four primary prevention and five tertiary prevention trials were included. Exercise had a small to moderate effect on improving concentrations of several blood biomarkers implicated in breast and colon cancer pathways including insulin, leptin, estrogens, and apoptosis regulation. In breast cancer survivors, exercise had a small to moderate effect on improving some biomarkers associated with prognosis including various insulin-like growth factor axis proteins, insulin, and inflammation; and a large effect on enhancing immune function. Conclusion: Data are few, but there is some evidence to support the role of exercise in modulating various cancer pathways. Springer Science+Business Media B.V., 2011 Exercise nationallicence Neoplasms nationallicence Prevention and control nationallicence Biologic markers nationallicence Survival nationallicence Winzer Brooke School of Medicine, Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, QLD, Australia aut Whiteman David Centre for Cancer Control, Queensland Institute of Medical Research, Brisbane, QLD, Australia aut Reeves Marina School of Population Health, Cancer Prevention Research Centre, The University of Queensland, Brisbane, QLD, Australia aut Paratz Jennifer School of Medicine, Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, QLD, Australia aut Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 811-826 0957-5243 22:6<811 2011 22 10552 https://doi.org/10.1007/s10552-011-9761-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9761-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Winzer Brooke School of Medicine, Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Whiteman David Centre for Cancer Control, Queensland Institute of Medical Research, Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Reeves Marina School of Population Health, Cancer Prevention Research Centre, The University of Queensland, Brisbane, QLD, Australia aut NATIONALLICENCE 700 1- Paratz Jennifer School of Medicine, Burns, Trauma & Critical Care Research Centre, The University of Queensland, Brisbane, QLD, Australia aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 811-826 0957-5243 22:6<811 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer