caa a22 4500 445314818 CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10552-011-9756-1 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9756-1 Association of tobacco habits, including bidi smoking, with overall and site-specific cancer incidence: results from the Mumbai cohort study [Elektronische Daten] [Mangesh Pednekar, Prakash Gupta, Balkrishna Yeole, James Hébert] Objective: Bidis are hand-rolled cigarettes commonly smoked in South Asia and are marketed to Western populations as a safer alternative to conventional cigarettes. This study examined the association between bidis and other forms of tobacco use and cancer incidence in an urban developing country population. Methods: Using data from the large, well-characterized Mumbai cohort study, adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were computed from Cox proportional hazards regression models in order to compare the relative effect of various forms of tobacco use on cancer incidence. Results: During 649,228 person-years of follow-up 1,267 incident cancers occurred in 87,222 male cohort members. Incident oral cancer in bidi smokers (HR=3.55; 95% CI=2.40,5.24) was 42% higher than in cigarette smokers (HR=2.50;95% CI=1.65,3.78). For all respiratory and intrathoracic organs combined, the increase was 69% (HR=5.54; 95% CI=3.46,8.87 vs. HR=3.28; 95% CI=1.99,5.39); for lung and larynx, the increases were 35 and 112%, respectively. Smokeless tobacco use was associated with cancers of the lip, oral cavity, pharynx, digestive, respiratory, and intrathoracic organs. Conclusions: Despite marketing claims to the contrary, we found that smokeless tobacco use and bidi smoking are at least as harmful as cigarette smoking for all incident cancers and are associated with increased risk of oral and respiratory/intrathoracic cancers. Springer Science+Business Media B.V., 2011 Public health nationallicence Disease incidence nationallicence Cancer nationallicence Tobacco nationallicence Cohort study nationallicence Pednekar Mangesh Healis, Sekhsaria Institute for Public Health, Navi Mumbai, Maharashtra, India aut Gupta Prakash Healis, Sekhsaria Institute for Public Health, Navi Mumbai, Maharashtra, India aut Yeole Balkrishna Indian Cancer Society, Bombay Population-Based Cancer Registry, Mumbai, Maharashtra, India aut Hébert James Healis, Sekhsaria Institute for Public Health, Navi Mumbai, Maharashtra, India aut Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 859-868 0957-5243 22:6<859 2011 22 10552 https://doi.org/10.1007/s10552-011-9756-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9756-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pednekar Mangesh Healis, Sekhsaria Institute for Public Health, Navi Mumbai, Maharashtra, India aut NATIONALLICENCE 700 1- Gupta Prakash Healis, Sekhsaria Institute for Public Health, Navi Mumbai, Maharashtra, India aut NATIONALLICENCE 700 1- Yeole Balkrishna Indian Cancer Society, Bombay Population-Based Cancer Registry, Mumbai, Maharashtra, India aut NATIONALLICENCE 700 1- Hébert James Healis, Sekhsaria Institute for Public Health, Navi Mumbai, Maharashtra, India aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/6(2011-06-01), 859-868 0957-5243 22:6<859 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer