caa a22 4500 445314826 CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10552-011-9795-7 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9795-7 Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia [Elektronische Daten] [Catherine Metayer, Ghislaine Scélo, Anand Chokkalingam, Lisa Barcellos, Melinda Aldrich, Jeffrey Chang, Neela Guha, Kevin Urayama, Helen Hansen, Gladys Block, Vincent Kiley, John Wiencke, Joseph Wiemels, Patricia Buffler] Objective: Folate is involved in the one-carbon metabolism that plays an essential role in the synthesis, repair, and methylation of DNA. We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk. Methods: Seventy-six single nucleotide polymorphisms (SNPs), including 66 haplotype-tagging SNPs in 10 genes (CBS, DHFR, FOLH1, MTHFD1, MTHFR, MTR, MTRR, SHMT1, SLC19A1, and TYMS), were genotyped in 377 ALL cases and 448 controls. Log-additive associations between genotypes and ALL risk were adjusted for age, sex, Hispanic ethnicity (when appropriate), and maternal race. Results: Single and haplotype SNPs analyses showed statistically significant associations between SNPs located in (or adjacent to) CBS, MTRR, TYMS/ENOFS, and childhood ALL. Many regions of CBS were associated with childhood ALL in Hispanics and non-Hispanics (p<0.01). Levels of maternal folate intake modified associations with SNPs in CBS, MTRR, and TYMS. Conclusion: Our data suggest the importance of genetic variability in the folate pathway and childhood ALL risk. Springer Science+Business Media B.V., 2011 Case-control study nationallicence Children nationallicence DNA methylation nationallicence Folate nationallicence Genetic polymorphisms nationallicence Leukemia nationallicence Metayer Catherine School of Public Health, University of California, Berkeley, 1995 University Avenue, Suite 460, 94704-7392, Berkeley, CA, USA aut Scélo Ghislaine International Agency for Research on Cancer, Lyon, France aut Chokkalingam Anand School of Public Health, University of California, Berkeley, Berkeley, CA, USA aut Barcellos Lisa School of Public Health, University of California, Berkeley, Berkeley, CA, USA aut Aldrich Melinda Division of Epidemiology, Institute for Medicine and Public Health, Vanderbilt University, Vanderbilt, TN, USA aut Chang Jeffrey National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan aut Guha Neela International Agency for Research on Cancer, Lyon, France aut Urayama Kevin International Agency for Research on Cancer, Lyon, France aut Hansen Helen Departments of Neurological Surgery & Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA aut Block Gladys School of Public Health, University of California, Berkeley, Berkeley, CA, USA aut Kiley Vincent Kaiser Permanente Hospital, Roseville, CA, USA aut Wiencke John Departments of Neurological Surgery & Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA aut Wiemels Joseph Departments of Neurological Surgery & Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA aut Buffler Patricia School of Public Health, University of California, Berkeley, Berkeley, CA, USA aut Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1243-1258 0957-5243 22:9<1243 2011 22 10552 https://doi.org/10.1007/s10552-011-9795-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9795-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Metayer Catherine School of Public Health, University of California, Berkeley, 1995 University Avenue, Suite 460, 94704-7392, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Scélo Ghislaine International Agency for Research on Cancer, Lyon, France aut NATIONALLICENCE 700 1- Chokkalingam Anand School of Public Health, University of California, Berkeley, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Barcellos Lisa School of Public Health, University of California, Berkeley, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Aldrich Melinda Division of Epidemiology, Institute for Medicine and Public Health, Vanderbilt University, Vanderbilt, TN, USA aut NATIONALLICENCE 700 1- Chang Jeffrey National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan aut NATIONALLICENCE 700 1- Guha Neela International Agency for Research on Cancer, Lyon, France aut NATIONALLICENCE 700 1- Urayama Kevin International Agency for Research on Cancer, Lyon, France aut NATIONALLICENCE 700 1- Hansen Helen Departments of Neurological Surgery & Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Block Gladys School of Public Health, University of California, Berkeley, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Kiley Vincent Kaiser Permanente Hospital, Roseville, CA, USA aut NATIONALLICENCE 700 1- Wiencke John Departments of Neurological Surgery & Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Wiemels Joseph Departments of Neurological Surgery & Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Buffler Patricia School of Public Health, University of California, Berkeley, Berkeley, CA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1243-1258 0957-5243 22:9<1243 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer