caa a22 4500 445314842 CHVBK 20180317142642.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10552-011-9805-9 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9805-9 The After Breast Cancer Pooling Project: rationale, methodology, and breast cancer survivor characteristics [Elektronische Daten] [Sarah Nechuta, Bette Caan, Wendy Chen, Shirley Flatt, Wei Lu, Ruth Patterson, Elizabeth Poole, Marilyn Kwan, Zhi Chen, Erin Weltzien, John Pierce, Xiao Shu] The After Breast Cancer Pooling Project was established to examine the role of physical activity, adiposity, dietary factors, supplement use, and quality of life (QOL) in breast cancer prognosis. This paper presents pooled and harmonized data on post-diagnosis lifestyle factors, clinical prognostic factors, and breast cancer outcomes from four prospective cohorts of breast cancer survivors (three US-based and one from Shanghai, China) for 18,314 invasive breast cancer cases diagnosed between 1976 and 2006. Most participants were diagnosed with stage I-II breast cancer (84.7%). About 60% of breast tumors were estrogen receptor (ER)+/progesterone receptor (PR)+; 21% were ER−/PR−. Among 8,118 participants with information on HER-2 tumor status, 74.8% were HER-2− and 18.5% were HER-2+. At 1-2years post-diagnosis (on average), 17.9% of participants were obese (BMI≥30kg/m2), 32.6% were overweight (BMI 25-29kg/m2), and 59.9% met the 2008 Physical Activity Guidelines for Americans (≥2.5h per week of moderate activity). During follow-up (mean=8.4years), 3,736 deaths (2,614 from breast cancer) and 3,564 recurrences have been documented. After accounting for differences in year of diagnosis and timing of post-diagnosis enrollment, five-year overall survival estimates were similar across cohorts. This pooling project of 18,000 breast cancer survivors enables the evaluation of associations of post-diagnosis lifestyle factors, QOL, and breast cancer outcomes with an adequate sample size for investigation of heterogeneity by hormone receptor status and other clinical predictors. The project sets the stage for international collaborations for the investigation of modifiable predictors for breast cancer outcomes. Springer Science+Business Media B.V., 2011 Breast neoplasm nationallicence Survival nationallicence Recurrence nationallicence Lifestyle nationallicence Nechuta Sarah Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, 37203-1738, Nashville, TN, USA aut Caan Bette Division of Research, Kaiser Permanente, 2000 Broadway, 94612, Oakland, CA, USA aut Chen Wendy Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 02115, Boston, MA, USA aut Flatt Shirley Cancer Prevention and Control Program, Moores UCSD Cancer Center, University of California, San Diego, 92093-0901, San Diego, CA, USA aut Lu Wei Shanghai Municipal Center for Disease Control and Prevention, 200336, Shanghai, China aut Patterson Ruth Cancer Prevention and Control Program, Moores UCSD Cancer Center, University of California, San Diego, 92093-0901, San Diego, CA, USA aut Poole Elizabeth Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 02115, Boston, MA, USA aut Kwan Marilyn Division of Research, Kaiser Permanente, 2000 Broadway, 94612, Oakland, CA, USA aut Chen Zhi Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, 37203-1738, Nashville, TN, USA aut Weltzien Erin Division of Research, Kaiser Permanente, 2000 Broadway, 94612, Oakland, CA, USA aut Pierce John Cancer Prevention and Control Program, Moores UCSD Cancer Center, University of California, San Diego, 92093-0901, San Diego, CA, USA aut Shu Xiao Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, 37203-1738, Nashville, TN, USA aut Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1319-1331 0957-5243 22:9<1319 2011 22 10552 https://doi.org/10.1007/s10552-011-9805-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9805-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nechuta Sarah Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, 37203-1738, Nashville, TN, USA aut NATIONALLICENCE 700 1- Caan Bette Division of Research, Kaiser Permanente, 2000 Broadway, 94612, Oakland, CA, USA aut NATIONALLICENCE 700 1- Chen Wendy Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Flatt Shirley Cancer Prevention and Control Program, Moores UCSD Cancer Center, University of California, San Diego, 92093-0901, San Diego, CA, USA aut NATIONALLICENCE 700 1- Lu Wei Shanghai Municipal Center for Disease Control and Prevention, 200336, Shanghai, China aut NATIONALLICENCE 700 1- Patterson Ruth Cancer Prevention and Control Program, Moores UCSD Cancer Center, University of California, San Diego, 92093-0901, San Diego, CA, USA aut NATIONALLICENCE 700 1- Poole Elizabeth Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Kwan Marilyn Division of Research, Kaiser Permanente, 2000 Broadway, 94612, Oakland, CA, USA aut NATIONALLICENCE 700 1- Chen Zhi Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, 37203-1738, Nashville, TN, USA aut NATIONALLICENCE 700 1- Weltzien Erin Division of Research, Kaiser Permanente, 2000 Broadway, 94612, Oakland, CA, USA aut NATIONALLICENCE 700 1- Pierce John Cancer Prevention and Control Program, Moores UCSD Cancer Center, University of California, San Diego, 92093-0901, San Diego, CA, USA aut NATIONALLICENCE 700 1- Shu Xiao Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, 37203-1738, Nashville, TN, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1319-1331 0957-5243 22:9<1319 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer