caa a22 4500 445314877 CHVBK 20180317142643.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10552-011-9793-9 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9793-9 Alternative approaches to assessing intervention effectiveness in randomized trials: application in a colorectal cancer screening study [Elektronische Daten] [Annette Maxwell, Catherine Crespi, Leda Danao, Cynthia Antonio, Gabriel Garcia, Roshan Bastani] Background: Previous analysis of a randomized community-based trial of a multi-component intervention to increase colorectal cancer (CRC) screening among Filipino Americans (n=548) found significantly higher screening rates in the two intervention groups compared to the control group, when using intent-to-treat analysis and self-reported screening as the outcome. This report describes more nuanced findings obtained from alternative approaches to assessing intervention effectiveness to inform future intervention implementation. Methods: The effect of the intervention on CRC screening receipt during follow-up was estimated using methods that adjusted for biases due to missing data and self-report and for different combinations of intervention components. Adjustment for self-report used data from a validation substudy. Effectiveness within demographic subgroups was also examined. Results: Analyses accounting for self-report bias and missing data supported the effectiveness of the intervention. The intervention was also broadly effective across the demographic characteristics of the sample. Estimates of the intervention effect were highest among participants whose providers received a letter as part of the intervention. Conclusions: The findings increase confidence that the intervention could be broadly effective at increasing CRC screening in this population. Subgroup analyses and attempts to deconstruct multi-component interventions can provide important information for future intervention development, implementation, and dissemination. Springer Science+Business Media B.V., 2011 Colorectal cancer nationallicence Cancer screening nationallicence Immigrants nationallicence Validation of self-report nationallicence Subgroup analysis nationallicence Maxwell Annette School of Public Health and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 650 Charles Young Dr. South, A2-125 CHS, Box 956900, 90095-6900, Los Angeles, CA, USA aut Crespi Catherine School of Public Health and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 650 Charles Young Dr. South, A2-125 CHS, Box 956900, 90095-6900, Los Angeles, CA, USA aut Danao Leda School of Public Health and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 650 Charles Young Dr. South, A2-125 CHS, Box 956900, 90095-6900, Los Angeles, CA, USA aut Antonio Cynthia School of Public Health and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 650 Charles Young Dr. South, A2-125 CHS, Box 956900, 90095-6900, Los Angeles, CA, USA aut Garcia Gabriel College of Health and Social Welfare, Department of Health Sciences, University of Alaska Anchorage, Anchorage, AK, USA aut Bastani Roshan School of Public Health and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 650 Charles Young Dr. South, A2-125 CHS, Box 956900, 90095-6900, Los Angeles, CA, USA aut Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1233-1241 0957-5243 22:9<1233 2011 22 10552 https://doi.org/10.1007/s10552-011-9793-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9793-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maxwell Annette School of Public Health and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 650 Charles Young Dr. South, A2-125 CHS, Box 956900, 90095-6900, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Crespi Catherine School of Public Health and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 650 Charles Young Dr. South, A2-125 CHS, Box 956900, 90095-6900, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Danao Leda School of Public Health and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 650 Charles Young Dr. South, A2-125 CHS, Box 956900, 90095-6900, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Antonio Cynthia School of Public Health and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 650 Charles Young Dr. South, A2-125 CHS, Box 956900, 90095-6900, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Garcia Gabriel College of Health and Social Welfare, Department of Health Sciences, University of Alaska Anchorage, Anchorage, AK, USA aut NATIONALLICENCE 700 1- Bastani Roshan School of Public Health and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 650 Charles Young Dr. South, A2-125 CHS, Box 956900, 90095-6900, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1233-1241 0957-5243 22:9<1233 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer