caa a22 4500 445314885 CHVBK 20180317142643.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10552-011-9799-3 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9799-3 Human immunoglobulin G levels of viruses and associated glioma risk [Elektronische Daten] [Sara Sjöström, Ulf Hjalmars, Per Juto, Göran Wadell, Göran Hallmans, Anne Tjönneland, Jytte Halkjaer, Jonas Manjer, Martin Almquist, Beatrice Melin] Few consistent etiological factors have been identified for primary brain tumors. Inverse associations to asthma and low levels of varicella-zoster virus, immunoglobulin (Ig) levels in prevalent cases have indicted a role for the immune system in the development of glioma. Because samples from prevalent cases of glioma could be influenced by treatments such as steroids and chemotherapy, we investigated pre-diagnostic samples from three large Scandinavian cohorts. To test the hypothesis that immune response levels to these viruses are associated etiologically with glioma risk, we investigated pre-diagnostic immunoglobulin levels for cytomegalovirus (CMV), varicella-zoster virus (VZV), adenovirus (Ad), and Epstein-Barr virus (EBV) including the nuclear antigen (EBNA1) using plasma samples from 197 cases of adult glioma and 394 controls collected from population-based cohorts in Sweden and Denmark. Low VZV IgG levels were marginally significantly more common in glioma cases than the controls (odds ratio (OR)=0.68, 95% CI 0.41-1.13) for the fourth compared with the first quartile (p=0.06 for trend). These results were more prominent when analyzing cases with blood sampling at least 2years before diagnosis (OR=0.63, 95% CI 0.37-1.08) (p=0.03). No association with glioma risk was observed for CMV, EBV, and adenovirus. The Author(s), 2011 Glioma nationallicence Glioblastoma nationallicence Immunoglobulin G nationallicence Virus nationallicence Case-control study nationallicence Sjöström Sara Department of Radiation Sciences, Oncology, Umeå University, 90187, Umeå, Sweden aut Hjalmars Ulf Department of Clinical Sciences, Paediatrics, Umeå University, 90187, Umeå, Sweden aut Juto Per Department of Clinical Microbiology, Umeå University, 90187, Umeå, Sweden aut Wadell Göran Department of Clinical Microbiology, Umeå University, 90187, Umeå, Sweden aut Hallmans Göran Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, 90187, Umeå, Sweden aut Tjönneland Anne Institute of Cancer Epidemiology, Danish Cancer Society, 2100, Copenhagen, Denmark aut Halkjaer Jytte Institute of Cancer Epidemiology, Danish Cancer Society, 2100, Copenhagen, Denmark aut Manjer Jonas Department of Surgery, Malmö University Hospital, Malmö University, Malmö, Sweden aut Almquist Martin Department of Surgery, Lund University Hospital, Lund University, Lund, Sweden aut Melin Beatrice Department of Radiation Sciences, Oncology, Umeå University, 90187, Umeå, Sweden aut Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1259-1266 0957-5243 22:9<1259 2011 22 10552 https://doi.org/10.1007/s10552-011-9799-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9799-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sjöström Sara Department of Radiation Sciences, Oncology, Umeå University, 90187, Umeå, Sweden aut NATIONALLICENCE 700 1- Hjalmars Ulf Department of Clinical Sciences, Paediatrics, Umeå University, 90187, Umeå, Sweden aut NATIONALLICENCE 700 1- Juto Per Department of Clinical Microbiology, Umeå University, 90187, Umeå, Sweden aut NATIONALLICENCE 700 1- Wadell Göran Department of Clinical Microbiology, Umeå University, 90187, Umeå, Sweden aut NATIONALLICENCE 700 1- Hallmans Göran Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, 90187, Umeå, Sweden aut NATIONALLICENCE 700 1- Tjönneland Anne Institute of Cancer Epidemiology, Danish Cancer Society, 2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Halkjaer Jytte Institute of Cancer Epidemiology, Danish Cancer Society, 2100, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Manjer Jonas Department of Surgery, Malmö University Hospital, Malmö University, Malmö, Sweden aut NATIONALLICENCE 700 1- Almquist Martin Department of Surgery, Lund University Hospital, Lund University, Lund, Sweden aut NATIONALLICENCE 700 1- Melin Beatrice Department of Radiation Sciences, Oncology, Umeå University, 90187, Umeå, Sweden aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1259-1266 0957-5243 22:9<1259 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer