caa a22 4500 445314907 CHVBK 20180317142643.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10552-011-9802-z doi (NATIONALLICENCE)springer-10.1007/s10552-011-9802-z Medical history and the risk of biliary tract cancers in Shanghai, China: implications for a role of inflammation [Elektronische Daten] [Gabriella Andreotti, Enju Liu, Yu-Tang Gao, Mahboobeh Safaeian, Asif Rashid, Ming-Chang Shen, Bin-Shen Wang, Jie Deng, Tian-Quian Han, Bai-He Zhang, Ann Hsing] Several lines of evidence suggest that inflammation may play a role in the etiology of biliary tract cancers. To examine further the role of inflammation, we evaluated the associations between self-reported inflammatory-related medical conditions and the risk of biliary tract cancers in a population-based case-control study in Shanghai, China. Our analysis included 368 gallbladder cancer cases, 191 bile duct cancer cases, 68 ampulla of Vater cancer cases, and 959 healthy subjects. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for biliary tract cancers in relation to six inflammation-related conditions. Gallbladder cancer was significantly associated with cholecystitis occurring at least 5years prior to interview (OR=1.7, 95% CI 1.1-2.9). Even though biliary stones did not significantly modify the associations between cholecystitis and gallbladder cancer, 90% of the gallbladder cancer cases with cholecystitis also had biliary stones, indicating that stones likely play an important role in the link between cholecystitis and gallbladder cancer. Among subjects who smoked and drank alcohol, a history of gastric (OR=4.3, 95% CI 1.2-15.0) or duodenal ulcers (OR=3.7, 1.2-12.0) was associated with an excess risk of gallbladder cancer. Although the mechanisms are unclear, our results further support the role for inflammation in the etiology of biliary tract cancers. Springer Science+Business Media B.V. (outside the USA), 2011 Biliary tract cancer nationallicence Biliary stones nationallicence Medical history nationallicence Inflammation nationallicence China nationallicence Andreotti Gabriella Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8011, MSC 7240, 20892, Bethesda, MD, USA aut Liu Enju Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China aut Gao Yu-Tang Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China aut Safaeian Mahboobeh Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8011, MSC 7240, 20892, Bethesda, MD, USA aut Rashid Asif Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA aut Shen Ming-Chang Shanghai Tumor Hospital, Fudan University, Shanghai, China aut Wang Bin-Shen Zhong Shan Hospital, Fudan University, Shanghai, China aut Deng Jie Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China aut Han Tian-Quian Department of Surgery, Rui Jin Hospital, Shanghai Second Medical University, Shanghai, China aut Zhang Bai-He Institute of East Hepatobiliary Surgery, Shanghai Second Military University, Shanghai, China aut Hsing Ann Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8011, MSC 7240, 20892, Bethesda, MD, USA aut Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1289-1296 0957-5243 22:9<1289 2011 22 10552 https://doi.org/10.1007/s10552-011-9802-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9802-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Andreotti Gabriella Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8011, MSC 7240, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Liu Enju Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China aut NATIONALLICENCE 700 1- Gao Yu-Tang Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China aut NATIONALLICENCE 700 1- Safaeian Mahboobeh Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8011, MSC 7240, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Rashid Asif Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA aut NATIONALLICENCE 700 1- Shen Ming-Chang Shanghai Tumor Hospital, Fudan University, Shanghai, China aut NATIONALLICENCE 700 1- Wang Bin-Shen Zhong Shan Hospital, Fudan University, Shanghai, China aut NATIONALLICENCE 700 1- Deng Jie Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China aut NATIONALLICENCE 700 1- Han Tian-Quian Department of Surgery, Rui Jin Hospital, Shanghai Second Medical University, Shanghai, China aut NATIONALLICENCE 700 1- Zhang Bai-He Institute of East Hepatobiliary Surgery, Shanghai Second Military University, Shanghai, China aut NATIONALLICENCE 700 1- Hsing Ann Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8011, MSC 7240, 20892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1289-1296 0957-5243 22:9<1289 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer