caa a22 4500 445314915 CHVBK 20180317142643.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10552-011-9803-y doi (NATIONALLICENCE)springer-10.1007/s10552-011-9803-y Lifetime physical activity and the incidence of proliferative benign breast disease [Elektronische Daten] [Michelle Jung, Graham Colditz, Laura Collins, Stuart Schnitt, James Connolly, Rulla Tamimi] Background: Exercise is a modifiable factor that is inversely related to risk for breast cancer. To determine if physical activity has a preventative effect on development of premalignant breast lesions, we examined the association between exercise and the incidence of proliferative benign breast disease. Methods: In 1997, the Nurses' Health Study II cohort reported levels of physical activity during adolescence and adulthood using a validated recall instrument. We followed 40,318 participants free from benign breast disease (BBD) or cancer prospectively for four years and confirmed 232 proliferative benign breast lesions by centralized pathology review. Cox proportional hazards models estimated the age-adjusted and multivariable-adjusted relative risks for physical activity and proliferative benign breast disease. Results: We observed a significant inverse association for walking and incidence of BBD, risk was reduced by 9% per hour of walking (95% CI 0% to 17%), (p trend=0.05). Despite a small number of cases, risk of columnar cell lesions also suggested an inverse association with strenuous activity (RR for 4 or more hours of strenuous activity per week=0.62; 0.31-1.22 compared to <1h per week). Conclusions: This study suggests that exercise may be inversely associated with the risk of developing proliferative benign breast disease, one of the earliest steps in the development of breast cancer. Springer Science+Business Media B.V., 2011 Physical activity nationallicence Premalignant breast diseases nationallicence Benign breast disease nationallicence Columnar cell lesions nationallicence Jung Michelle Alvin J. Siteman Cancer Center and Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut Colditz Graham Alvin J. Siteman Cancer Center and Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut Collins Laura Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA aut Schnitt Stuart Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA aut Connolly James Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA aut Tamimi Rulla Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1297-1305 0957-5243 22:9<1297 2011 22 10552 https://doi.org/10.1007/s10552-011-9803-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9803-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jung Michelle Alvin J. Siteman Cancer Center and Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Colditz Graham Alvin J. Siteman Cancer Center and Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Collins Laura Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Schnitt Stuart Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Connolly James Department of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Tamimi Rulla Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1297-1305 0957-5243 22:9<1297 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer