caa a22 4500 445314923 CHVBK 20180317142643.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10552-011-9800-1 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9800-1 Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels with risk of malignant melanoma [Elektronische Daten] [Sungshim Park, Veronica Setiawan, Peter Kanetsky, Zuo-Feng Zhang, Lynne Wilkens, Laurence Kolonel, Loïc Le Marchand] We examined the relationship of insulin-like growth factor-I (IGF-I) and its primary growth factor, IGF binding protein-3 (IGFBP-3) with malignant melanoma using interview data and sera from cases (n=286) and controls (n=289) in a population-based case-control study conducted in 1986-1992 on Oahu, Hawaii. Serum IGF-I and IGFBP-3 concentrations were measured by ELISA. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional logistic regression and adjusting for age, sex, education, number of blistering sunburns, ability to tan, hair color, energy intake, BMI, height, smoking status, and drinking status. An inverse relationship was found between IGF-I concentration and melanoma (OR for upper vs. lower tertile: 0.44, 95% CI: 0.25-0.79), but clear associations were not observed between malignant melanoma and upper tertiles of IGFBP-3 and the IGF-1/IGFBP-3 molar ratio. The inverse association with IGF-I was strongest among subjects who did not report a history of non-melanoma skin cancer (NMSC) (OR for ≥ vs. < median: 0.39, 95% CI: 0.24-0.65), and a positive association was found among those with such a history (OR: 3.6, 95% CI: 1.0-13; p interaction=0.0035). Our findings observed here between serum IGF-I and malignant melanoma warrants replication in studies with a larger sample size and a prospective design. Springer Science+Business Media B.V., 2011 Malignant melanoma nationallicence Insulin-like growth factor-I (IGF-I) nationallicence Insulin-like growth factor binding protein-3 (IGFBP-3) nationallicence IGF-I : Insulin-like growth factor-I nationallicence IGFBP-3 : Insulin-like growth factor binding protein-3 nationallicence ELISA : Enzyme-linked immunosorbent assay nationallicence OR : Odds ratio nationallicence CI : Confidence interval nationallicence NMSC : Non-melanoma skin cancer nationallicence BMI : Body mass index nationallicence Park Sungshim Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Suite 407, 96813, Honolulu, HI, USA aut Setiawan Veronica Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA aut Kanetsky Peter Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut Zhang Zuo-Feng Department of Epidemiology, School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA, USA aut Wilkens Lynne Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Suite 407, 96813, Honolulu, HI, USA aut Kolonel Laurence Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Suite 407, 96813, Honolulu, HI, USA aut Le Marchand Loïc Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Suite 407, 96813, Honolulu, HI, USA aut Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1267-1275 0957-5243 22:9<1267 2011 22 10552 https://doi.org/10.1007/s10552-011-9800-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9800-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Park Sungshim Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Suite 407, 96813, Honolulu, HI, USA aut NATIONALLICENCE 700 1- Setiawan Veronica Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Kanetsky Peter Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Zhang Zuo-Feng Department of Epidemiology, School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Wilkens Lynne Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Suite 407, 96813, Honolulu, HI, USA aut NATIONALLICENCE 700 1- Kolonel Laurence Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Suite 407, 96813, Honolulu, HI, USA aut NATIONALLICENCE 700 1- Le Marchand Loïc Epidemiology Program, University of Hawaii Cancer Center, 1236 Lauhala Street, Suite 407, 96813, Honolulu, HI, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/9(2011-09-01), 1267-1275 0957-5243 22:9<1267 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer