caa a22 4500 445314974 CHVBK 20180317142643.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10552-011-9767-y doi (NATIONALLICENCE)springer-10.1007/s10552-011-9767-y Levels of insulin-like growth factor during pregnancy and maternal cancer risk: a nested case-control study [Elektronische Daten] [Mona Jeffreys, Kate Northstone, Jeffrey Holly, Pauline Emmett, David Gunnell] Previous studies have suggested that pregnancy measures of insulin-like growth factors (IGFs) may be related to breast cancer risk in mothers. IGFs may also be important in cervical cancer etiology. We conducted a nested case-control study (69 breast cancer cases, 151 cervical cancer cases, 443 controls) among mothers of the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Over 70% of blood samples was taken prior to 15weeks' gestation; the remainder before 30weeks. Logistic regression, controlling for maternal age, gestational age, and sample type (plasma/serum) was used to model the association between IGFs and maternal cancer risk. Neither IGF-I nor IGF-II were associated with breast or cervical cancer. IGF-binding protein (BP)-3 was not related to breast cancer, but there was a suggestion that women in the highest compared to lowest quartile of IGFBP-3 had reduced risk of cervical cancer, OR 0.43 (95% CI 0.21-0.86). In conclusion, the importance of IGFs measured in pregnancy and later breast and cervical cancer remains unclear, though IGFBP-3 may be a marker of lowered risk. Springer Science+Business Media B.V., 2011 Insulin-like growth factor nationallicence IGF-I nationallicence IGF-II nationallicence IGFBP-3 nationallicence Pregnancy nationallicence ALSPAC nationallicence Breast cancer nationallicence Cervical cancer nationallicence Jeffreys Mona School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Rd, BS8 2PS, Bristol, UK aut Northstone Kate School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Rd, BS8 2PS, Bristol, UK aut Holly Jeffrey School of Clinical Sciences, Southmead Hospital, University of Bristol, Learning & Research Building, BS10 5NB, Bristol, UK aut Emmett Pauline School of Social and Community Medicine, University of Bristol, Barley House, Oakfield Grove, BS8 2BN, Bristol, UK aut Gunnell David School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Rd, BS8 2PS, Bristol, UK aut Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 945-953 0957-5243 22:7<945 2011 22 10552 https://doi.org/10.1007/s10552-011-9767-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9767-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jeffreys Mona School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Rd, BS8 2PS, Bristol, UK aut NATIONALLICENCE 700 1- Northstone Kate School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Rd, BS8 2PS, Bristol, UK aut NATIONALLICENCE 700 1- Holly Jeffrey School of Clinical Sciences, Southmead Hospital, University of Bristol, Learning & Research Building, BS10 5NB, Bristol, UK aut NATIONALLICENCE 700 1- Emmett Pauline School of Social and Community Medicine, University of Bristol, Barley House, Oakfield Grove, BS8 2BN, Bristol, UK aut NATIONALLICENCE 700 1- Gunnell David School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Rd, BS8 2PS, Bristol, UK aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 945-953 0957-5243 22:7<945 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer