caa a22 4500 445314990 CHVBK 20180317142643.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10552-011-9772-1 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9772-1 Dietary carbohydrate, glycemic index, glycemic load, and risk of prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort [Elektronische Daten] [James Shikany, Andrew Flood, Cari Kitahara, Ann Hsing, Tamra Meyer, Bradley Willcox, David Redden, Regina Ziegler] Objective: To evaluate the associations between dietary carbohydrate, glycemic index (GI), glycemic load (GL), and incident prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. Methods: Between September 1993 and September 2000, 38,343 men were randomized to the screening arm of the trial at one of 10 PLCO centers. A food frequency questionnaire administered at baseline assessed usual dietary intake over the preceding 12months. Prostate cancer was ascertained by medical follow-up of suspicious screening results and annual mailed questionnaires and confirmed with medical records. Cox proportional hazards regression was used to model the associations of carbohydrate, GI, and GL with prostate cancer risk. Results: During follow-up (median=9.2years), 2,436 incident prostate cancers were identified among 30,482 eligible participants. Overall, there were no associations of baseline carbohydrate, GI, or GL with incident prostate cancer in minimally or fully adjusted models. There were no associations when the 228 advanced and 2,208 non-advanced cancers were analyzed separately. Conclusions: Dietary carbohydrate, GI, and GL were not associated with incident prostate cancer in PLCO. The narrow range of GI in this cohort may have limited our ability to detect associations, an issue that future studies should address. Springer Science+Business Media B.V., 2011 Prostatic neoplasms nationallicence Dietary carbohydrates nationallicence Glycemic index nationallicence Shikany James Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, 1530 3rd Ave. S., MT 610, 35294, Birmingham, AL, USA aut Flood Andrew Division of Epidemiology and Community Health, Department of Food Science and Nutrition, University of Minnesota, 55454, St. Paul, MN, USA aut Kitahara Cari Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 20852, Rockville, MD, USA aut Hsing Ann Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 20852, Rockville, MD, USA aut Meyer Tamra Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 20852, Rockville, MD, USA aut Willcox Bradley Pacific Health Research Institute, The Queen's Medical Center, 96813, Honolulu, HI, USA aut Redden David Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, 35294, Birmingham, AL, USA aut Ziegler Regina Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 20852, Rockville, MD, USA aut Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 995-1002 0957-5243 22:7<995 2011 22 10552 https://doi.org/10.1007/s10552-011-9772-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9772-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shikany James Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, 1530 3rd Ave. S., MT 610, 35294, Birmingham, AL, USA aut NATIONALLICENCE 700 1- Flood Andrew Division of Epidemiology and Community Health, Department of Food Science and Nutrition, University of Minnesota, 55454, St. Paul, MN, USA aut NATIONALLICENCE 700 1- Kitahara Cari Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 20852, Rockville, MD, USA aut NATIONALLICENCE 700 1- Hsing Ann Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 20852, Rockville, MD, USA aut NATIONALLICENCE 700 1- Meyer Tamra Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 20852, Rockville, MD, USA aut NATIONALLICENCE 700 1- Willcox Bradley Pacific Health Research Institute, The Queen's Medical Center, 96813, Honolulu, HI, USA aut NATIONALLICENCE 700 1- Redden David Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, 35294, Birmingham, AL, USA aut NATIONALLICENCE 700 1- Ziegler Regina Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 20852, Rockville, MD, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 995-1002 0957-5243 22:7<995 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer