caa a22 4500 445315008 CHVBK 20180317142643.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10552-011-9779-7 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9779-7 Alcohol and tobacco, and the risk of cancers of the upper aerodigestive tract in Latin America: a case-control study [Elektronische Daten] [K. Szymańska, R. Hung, V. Wünsch-Filho, J. Eluf-Neto, M. Curado, S. Koifman, E. Matos, A. Menezes, L. Fernandez, A. Daudt, P. Boffetta, P. Brennan] Background: Cancers of the upper aerodigestive tract (UADT; including oral cavity, pharynx, larynx and oesophagus) have high incidence rates all over the world, and they are especially frequent in some parts of Latin America. However, the data on the role of the major risk factors in these areas are still limited. Methods: We have evaluated the role of alcohol and tobacco consumption, based on 2,252 upper aerodigestive squamous-cell carcinoma cases and 1,707 controls from seven centres in Brazil, Argentina, and Cuba. Results: We show that alcohol drinkers have a risk of UADT cancers that is up to five times higher than that of never-drinkers. A very strong effect of aperitifs and spirits as compared to other alcohol types was observed, with the ORs reaching 12.76 (CI 5.37-30.32) for oesophagus. Tobacco smokers were up to six times more likely to develop aerodigestive cancers than never-smokers, with the ORs reaching 11.14 (7.72-16.08) among current smokers for hypopharynx and larynx cancer. There was a trend for a decrease in risk after quitting alcohol drinking or tobacco smoking for all sites. The interactive effect of alcohol and tobacco was more than multiplicative. In this study, 65% of all UADT cases were attributable to a combined effect of alcohol and tobacco use. Conclusions: In this largest study on UADT cancer in Latin America, we have shown for the first time that a prevailing majority of UADT cancer cases is due to a combined effect of alcohol and tobacco use and could be prevented by quitting the use of either of these two agents. Springer Science+Business Media B.V., 2011 Upper aerodigestive tract nationallicence South America nationallicence Tobacco nationallicence Alcohol nationallicence Cancer nationallicence UADT : Upper aerodigestive tract nationallicence SCC : Squamous-cell carcinoma nationallicence OR : Odds ratio nationallicence CI : Confidence interval nationallicence Szymańska K. International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69008, Lyon Cedex, France aut Hung R. International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69008, Lyon Cedex, France aut Wünsch-Filho V. Universidade de São Paolo, São Paolo, Brazil aut Eluf-Neto J. Universidade de São Paolo, São Paolo, Brazil aut Curado M. International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69008, Lyon Cedex, France aut Koifman S. School of Public Health, Rio de Janeiro, Brazil aut Matos E. University of Buenos Aires, Buenos Aires, Argentina aut Menezes A. Federal University of Pelotas, Pelotas, Brazil aut Fernandez L. Institute of Oncology and Radiobiology, La Havana, Cuba aut Daudt A. Clinical Hospital of Porto Alegre, Porto Alegre, Brazil aut Boffetta P. International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69008, Lyon Cedex, France aut Brennan P. International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69008, Lyon Cedex, France aut Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 1037-1046 0957-5243 22:7<1037 2011 22 10552 https://doi.org/10.1007/s10552-011-9779-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9779-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Szymańska K. International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69008, Lyon Cedex, France aut NATIONALLICENCE 700 1- Hung R. International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69008, Lyon Cedex, France aut NATIONALLICENCE 700 1- Wünsch-Filho V. Universidade de São Paolo, São Paolo, Brazil aut NATIONALLICENCE 700 1- Eluf-Neto J. Universidade de São Paolo, São Paolo, Brazil aut NATIONALLICENCE 700 1- Curado M. International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69008, Lyon Cedex, France aut NATIONALLICENCE 700 1- Koifman S. School of Public Health, Rio de Janeiro, Brazil aut NATIONALLICENCE 700 1- Matos E. University of Buenos Aires, Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Menezes A. Federal University of Pelotas, Pelotas, Brazil aut NATIONALLICENCE 700 1- Fernandez L. Institute of Oncology and Radiobiology, La Havana, Cuba aut NATIONALLICENCE 700 1- Daudt A. Clinical Hospital of Porto Alegre, Porto Alegre, Brazil aut NATIONALLICENCE 700 1- Boffetta P. International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69008, Lyon Cedex, France aut NATIONALLICENCE 700 1- Brennan P. International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69008, Lyon Cedex, France aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 1037-1046 0957-5243 22:7<1037 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer