caa a22 4500 445315024 CHVBK 20180317142643.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10552-011-9768-x doi (NATIONALLICENCE)springer-10.1007/s10552-011-9768-x Variation in the CYP19A1 gene and risk of colon and rectal cancer [Elektronische Daten] [Martha Slattery, Abbie Lundgreen, Jennifer Herrick, Susan Kadlubar, Bette Caan, John Potter, Roger Wolff] CYP19A1, or aromatase, influences estrogen-metabolizing enzymes and may influence cancer risk. We examine variation in the CYP19A1 gene and risk of colorectal cancer using data from population-based case-control studies (colon n=1,574 cases, 1,970 controls; rectal n=791 cases, 999 controls). Four SNPs were statistically significantly associated with colon cancer and four were associated with rectal cancer. After adjustment for multiple comparisons, the AA genotype of rs12591359 was associated with an increased risk of colon cancer (OR 1.44 95% CI 1.16-1.80) and the AA genotype of rs2470144 was associated with a reduced risk of rectal cancer (OR 0.65 95% CI 0.50-0.84). Variants of CYP19A1 were associated with CIMP+ and CIMP+/KRAS2-mutated tumors. CT/TT genotypes of rs1961177 were significantly associated with an increased likelihood of a MSI+ colon tumor (OR 1.77 95% CI 1.26-2.37). We observed statistically significant interactions between genetic variation in NFκB1 and CYP19A1 for both colon and rectal cancer. Our data suggest the importance of CYP19A1 in the development of colon and rectal cancer and that estrogen may influence risk through an inflammation-related mechanism. Springer Science+Business Media B.V., 2011 Colon cancer nationallicence Rectal cancer nationallicence CYP19A1 nationallicence NFκB1 nationallicence Aspirin nationallicence BMI nationallicence CIMP+ nationallicence KRAS2 nationallicence MSI nationallicence Slattery Martha Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, 84108, Salt Lake City, UT, USA aut Lundgreen Abbie Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, 84108, Salt Lake City, UT, USA aut Herrick Jennifer Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, 84108, Salt Lake City, UT, USA aut Kadlubar Susan University of Arkansas, Little Rock, AR, USA aut Caan Bette Division of Research, Kaiser Permanente Medical Research Program, Oakland, CA, USA aut Potter John Fred Hutchinson Cancer Research Center, Seattle, WA, USA aut Wolff Roger Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, 84108, Salt Lake City, UT, USA aut Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 955-963 0957-5243 22:7<955 2011 22 10552 https://doi.org/10.1007/s10552-011-9768-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9768-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Slattery Martha Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, 84108, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Lundgreen Abbie Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, 84108, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Herrick Jennifer Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, 84108, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Kadlubar Susan University of Arkansas, Little Rock, AR, USA aut NATIONALLICENCE 700 1- Caan Bette Division of Research, Kaiser Permanente Medical Research Program, Oakland, CA, USA aut NATIONALLICENCE 700 1- Potter John Fred Hutchinson Cancer Research Center, Seattle, WA, USA aut NATIONALLICENCE 700 1- Wolff Roger Department of Internal Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, 84108, Salt Lake City, UT, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 955-963 0957-5243 22:7<955 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer