caa a22 4500 445315032 CHVBK 20180317142643.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10552-011-9777-9 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9777-9 Adiposity and the risk of colorectal adenomatous polyps: a meta-analysis [Elektronische Daten] [Yeon Lee, Seung-Kwon Myung, BeLong Cho, Byung-Joo Park, Jin Park, Woong Ju, Min-Sun Park, Ji-Ho Choi] Objective: The findings from epidemiological studies addressing the association between adiposity and the risk of colorectal adenomatous polyps are inconsistent. We performed a meta-analysis of epidemiological studies including cross-sectional, case-control, and cohort studies. Methods: We searched PubMed and EMBASE in June, 2010. All searched articles were reviewed and selected independently by two evaluators according to pre-determined selection criteria. Results: We included 25 studies (nine cross-sectional studies, eleven case-control studies, and five prospective cohort studies) that comprised a total of 300,671 participants and 20,903 cases in the final analysis. When all studies were pooled, the odds ratio (OR) or relative risk (RR) of adiposity and abdominal adiposity for colorectal adenomatous polyp risk was 1.43 (95% confidence interval (CI) 1.23-1.67; n=22) and 1.42 (95% CI 1.30-1.56; n=12), respectively. Similarly, an increased risk of colorectal adenomatous polyps was observed in most of the subgroup meta-analyses. Conclusions: Overall, we found that adiposity and abdominal adiposity significantly increased the risk of colorectal adenomatous polyps in a meta-analysis of epidemiological studies. Springer Science+Business Media B.V., 2011 Adiposity nationallicence Abdominal adiposity nationallicence Colorectal adenomatous polyps nationallicence Meta-analysis nationallicence Lee Yeon Department of Family Medicine, School of Medicine, Inha University, Incheon, Republic of Korea aut Myung Seung-Kwon Cancer Epidemiology Branch, Research Institute, Smoking Cessation Clinic, Family Medicine Clinic, and Center for Cancer Prevention and Detection, Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, 410-769, Goyang, Gyeonggi-do, Republic of Korea aut Cho BeLong Health Promotion Center, Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea aut Park Byung-Joo Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea aut Park Jin Health Promotion Center, Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea aut Ju Woong Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea aut Park Min-Sun Health Promotion Center, Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea aut Choi Ji-Ho Department of Family Medicine, School of Medicine, Inha University, Incheon, Republic of Korea aut Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 1021-1035 0957-5243 22:7<1021 2011 22 10552 https://doi.org/10.1007/s10552-011-9777-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9777-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Yeon Department of Family Medicine, School of Medicine, Inha University, Incheon, Republic of Korea aut NATIONALLICENCE 700 1- Myung Seung-Kwon Cancer Epidemiology Branch, Research Institute, Smoking Cessation Clinic, Family Medicine Clinic, and Center for Cancer Prevention and Detection, Hospital, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, 410-769, Goyang, Gyeonggi-do, Republic of Korea aut NATIONALLICENCE 700 1- Cho BeLong Health Promotion Center, Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Park Byung-Joo Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Park Jin Health Promotion Center, Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Ju Woong Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Park Min-Sun Health Promotion Center, Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Choi Ji-Ho Department of Family Medicine, School of Medicine, Inha University, Incheon, Republic of Korea aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 1021-1035 0957-5243 22:7<1021 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer