caa a22 4500 445315059 CHVBK 20180317142643.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10552-011-9773-0 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9773-0 Association between psoriasis and incident cancer: the Iowa's Women's Health Study [Elektronische Daten] [Anna Prizment, Alvaro Alonso, Aaron Folsom, Rehana Ahmed, Beth Virnig, Erin Warshaw, Kristin Anderson] Introduction: Studies have reported higher cancer risk in individuals with psoriasis, a chronic inflammatory autoimmune disease; however, adjustment for potential confounders was lacking. Methods: We examined the association of psoriasis with cancer incidence in 32,910 women after age 65 in the IWHS cohort linked to Medicare. Psoriasis was defined as: 2+ psoriasis claims from any Medicare file during 1991-2004 or 1+ psoriasis claim from a dermatologist (n=719). Severe psoriasis was defined as 4+ psoriasis claims from a dermatologist in any year (n=121). Cox proportional hazards regression, with psoriasis as a time-dependent variable was conducted to calculate hazard ratios (HR) and 95% confidence intervals (CI) of total (n=6,488), breast (n=2,066), lung (n=742), and colon cancers (n=947). Results: With age-adjustment, psoriasis (yes vs. no) was associated with increased risk of lung 1.9 (95% CI: 1.2-3.0), colon 1.6 (95% CI: 1.1-2.5), and total cancer 1.2 (95% CI, 1.0-1.4). After further adjustment for smoking, body mass index, education, physical activity, and hormone therapy use, only the association for colon cancer remained statistically significant (HR=1.6, 95% CI: 1.0-2.4) and was stronger for severe psoriasis. Conclusion: The observed association between psoriasis and colon cancer may reflect inflammatory or unidentified processes. Springer Science+Business Media B.V., 2011 Colon cancer nationallicence Inflammation nationallicence Psoriasis nationallicence Immune disease nationallicence Medicare nationallicence Prizment Anna Division of Epidemiology and Community Health, University of Minnesota, 1300 2nd Street South, Suite 300, 55455, Minneapolis, MN, USA aut Alonso Alvaro Division of Epidemiology and Community Health, University of Minnesota, 1300 2nd Street South, Suite 300, 55455, Minneapolis, MN, USA aut Folsom Aaron Division of Epidemiology and Community Health, University of Minnesota, 1300 2nd Street South, Suite 300, 55455, Minneapolis, MN, USA aut Ahmed Rehana Department of Dermatology, University of Minnesota, Minneapolis, MN, USA aut Virnig Beth Division of Health Policy and Management, University of Minnesota, Minneapolis, MN, USA aut Warshaw Erin Department of Dermatology, University of Minnesota, Minneapolis, MN, USA aut Anderson Kristin Division of Epidemiology and Community Health, University of Minnesota, 1300 2nd Street South, Suite 300, 55455, Minneapolis, MN, USA aut Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 1003-1010 0957-5243 22:7<1003 2011 22 10552 https://doi.org/10.1007/s10552-011-9773-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9773-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Prizment Anna Division of Epidemiology and Community Health, University of Minnesota, 1300 2nd Street South, Suite 300, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Alonso Alvaro Division of Epidemiology and Community Health, University of Minnesota, 1300 2nd Street South, Suite 300, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Folsom Aaron Division of Epidemiology and Community Health, University of Minnesota, 1300 2nd Street South, Suite 300, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Ahmed Rehana Department of Dermatology, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Virnig Beth Division of Health Policy and Management, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Warshaw Erin Department of Dermatology, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Anderson Kristin Division of Epidemiology and Community Health, University of Minnesota, 1300 2nd Street South, Suite 300, 55455, Minneapolis, MN, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 1003-1010 0957-5243 22:7<1003 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer