caa a22 4500 445315091 CHVBK 20180317142643.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10552-011-9778-8 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9778-8 Telomere length in peripheral blood and breast cancer risk in a prospective case-cohort analysis: results from the Sister Study [Elektronische Daten] [Sangmi Kim, Dale Sandler, Gleta Carswell, Lisa De Roo, Christine Parks, Richard Cawthon, Clarice Weinberg, Jack Taylor] Objective: Telomeres are required for maintaining genomic integrity and may play a role in carcinogenesis. Some, but not all, epidemiologic studies have found that short telomeres in leukocytes are associated with an increased risk of breast cancer. To further elucidate this potential association, we examined telomere length in relation to breast cancer risk in prospectively collected blood samples from the Sister Study, a cohort of women aged 35-74years who have a sister with breast cancer. Methods: We performed a case-cohort analysis comparing incident breast cancer cases (n=342) with a subcohort (n=735), randomly selected from 29,026 participants, enrolled by June 1, 2007. Relative telomere length in peripheral blood cells was estimated using a single-tube monochrome multiplex quantitative PCR assay. Results: No association was observed between telomere length and breast cancer risk. Compared with the longest quartile, hazard ratios (HR) associated with the second, third, and the shortest quartile were 0.91 [95% confidence interval (95% CI): 0.62-1.34], 1.11 (95% CI: 0.77-1.60), and 0.93 (95% CI: 0.64-1.35), respectively. Subgroup analyses by menopausal status, invasiveness, or estrogen receptor status of breast cancer did not reveal evidence of association between telomere length in blood cells and subsequent breast cancer risk. Conclusions: This prospective investigation does not support telomere length in blood cells as a biomarker for breast cancer risk. Springer Science+Business Media B.V. (outside the USA), 2011 Breast cancer nationallicence Telomere length nationallicence Prospective study nationallicence Biomarker nationallicence qPCR nationallicence Kim Sangmi Epidemiology Branch, National Institute of Environmental Health Sciences, MD A3-05, 111 T.W. Alexander Drive, PO Box 12233, 27709, Research Triangle Park, NC, USA aut Sandler Dale Epidemiology Branch, National Institute of Environmental Health Sciences, MD A3-05, 111 T.W. Alexander Drive, PO Box 12233, 27709, Research Triangle Park, NC, USA aut Carswell Gleta Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA aut De Roo Lisa Epidemiology Branch, National Institute of Environmental Health Sciences, MD A3-05, 111 T.W. Alexander Drive, PO Box 12233, 27709, Research Triangle Park, NC, USA aut Parks Christine Epidemiology Branch, National Institute of Environmental Health Sciences, MD A3-05, 111 T.W. Alexander Drive, PO Box 12233, 27709, Research Triangle Park, NC, USA aut Cawthon Richard University of Utah, Salt Lake City, UT, USA aut Weinberg Clarice Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA aut Taylor Jack Epidemiology Branch, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA aut Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 1061-1066 0957-5243 22:7<1061 2011 22 10552 https://doi.org/10.1007/s10552-011-9778-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9778-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Sangmi Epidemiology Branch, National Institute of Environmental Health Sciences, MD A3-05, 111 T.W. Alexander Drive, PO Box 12233, 27709, Research Triangle Park, NC, USA aut NATIONALLICENCE 700 1- Sandler Dale Epidemiology Branch, National Institute of Environmental Health Sciences, MD A3-05, 111 T.W. Alexander Drive, PO Box 12233, 27709, Research Triangle Park, NC, USA aut NATIONALLICENCE 700 1- Carswell Gleta Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA aut NATIONALLICENCE 700 1- De Roo Lisa Epidemiology Branch, National Institute of Environmental Health Sciences, MD A3-05, 111 T.W. Alexander Drive, PO Box 12233, 27709, Research Triangle Park, NC, USA aut NATIONALLICENCE 700 1- Parks Christine Epidemiology Branch, National Institute of Environmental Health Sciences, MD A3-05, 111 T.W. Alexander Drive, PO Box 12233, 27709, Research Triangle Park, NC, USA aut NATIONALLICENCE 700 1- Cawthon Richard University of Utah, Salt Lake City, UT, USA aut NATIONALLICENCE 700 1- Weinberg Clarice Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA aut NATIONALLICENCE 700 1- Taylor Jack Epidemiology Branch, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 1061-1066 0957-5243 22:7<1061 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer