caa a22 4500 445315105 CHVBK 20180317142643.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10552-011-9770-3 doi (NATIONALLICENCE)springer-10.1007/s10552-011-9770-3 The association of diabetes mellitus and high-grade prostate cancer in a multiethnic biopsy series [Elektronische Daten] [Daniel Moreira, Tiffany Anderson, Leah Gerber, Jean-Alfred Thomas, Lionel Bañez, Madeline McKeever, Cathrine Hoyo, Delores Grant, Jayakrishnan Jayachandran, Stephen Freedland] Objective: To analyze the association of diabetes mellitus (DM) with risk of prostate cancer and cancer grade among men undergoing prostate biopsy and to analyze how obesity and race modify these associations. Materials and methods: Retrospective analysis of 998 men from the Durham VA undergoing first prostate biopsy between 2001 and 2009 with complete data available. History of DM was determined by chart review. Patients' characteristics at biopsy were analyzed with chi-square and ranksum. Multivariable analyses of DM and risk of cancer and cancer grade were done using logistic regression adjusting for PSA, body mass index, race, age, year, and digital rectal exam. Results: At biopsy, 284 (28%) men had DM. DM was associated with African American (AAM; p=0.010) and higher BMI (p<0.001). DM was not associated with prostate cancer risk on either bivariate (p=0.600) or multivariate analysis (p=0.485). Similar results were found after stratification by race and obesity. In multivariable analysis, DM was associated with greater risk of high-grade disease (RR=2.13, p=0.024). The association was stronger among obese men (RR=3.84, p=0.020) and null in non-obese subjects (RR=1.39, p=0.460). After further stratification by race, DM was associated with high-grade disease only in obese Caucasian men (CM; RR=5.81, p=0.025) but not in obese AAM. DM was not associated with risk of low-grade disease in all men together or after stratification by obesity or race. Conclusion: History of DM was associated with greater risk of high-grade disease. The association was strongest among obese CM suggesting the effect of DM on high-grade prostate cancer is modified by race and obesity. Springer Science+Business Media B.V. (outside the USA), 2011 Prostatic neoplasm nationallicence Prostate-specific antigen nationallicence Diabetes Mellitus nationallicence Incidence nationallicence Epidemiology nationallicence Case-control studies nationallicence Obesity nationallicence Population groups nationallicence Ethnic groups nationallicence Continental population groups nationallicence Male nationallicence Moreira Daniel Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut Anderson Tiffany Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut Gerber Leah Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut Thomas Jean-Alfred Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut Bañez Lionel Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut McKeever Madeline Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut Hoyo Cathrine Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA aut Grant Delores JLC-Biomedical/Biotechnology Research Institute, Cancer Research Program, North Carolina Central University, Durham, NC, USA aut Jayachandran Jayakrishnan Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut Freedland Stephen Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 977-983 0957-5243 22:7<977 2011 22 10552 https://doi.org/10.1007/s10552-011-9770-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10552-011-9770-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moreira Daniel Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut NATIONALLICENCE 700 1- Anderson Tiffany Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut NATIONALLICENCE 700 1- Gerber Leah Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut NATIONALLICENCE 700 1- Thomas Jean-Alfred Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut NATIONALLICENCE 700 1- Bañez Lionel Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut NATIONALLICENCE 700 1- McKeever Madeline Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut NATIONALLICENCE 700 1- Hoyo Cathrine Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA aut NATIONALLICENCE 700 1- Grant Delores JLC-Biomedical/Biotechnology Research Institute, Cancer Research Program, North Carolina Central University, Durham, NC, USA aut NATIONALLICENCE 700 1- Jayachandran Jayakrishnan Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut NATIONALLICENCE 700 1- Freedland Stephen Division of Urologic Surgery, Department of Surgery and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA aut NATIONALLICENCE 773 0- Cancer Causes & Control Springer Netherlands 22/7(2011-07-01), 977-983 0957-5243 22:7<977 2011 22 10552 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer